CAS 485-47-2|Ninhydrin
Introduction：Basic information about CAS 485-47-2|Ninhydrin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ninhydrin | ||
|---|---|---|---|
| CAS Number | 485-47-2 | Molecular Weight | 178.141 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 449.3±45.0 °C at 760 mmHg |
| Molecular Formula | C9H6O4 | Melting Point | 250 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 239.7±25.2 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | ninhydrin |
|---|---|
| Synonym | More Synonyms |
Ninhydrin BiologicalActivity
| Description | Ninhydrin can be used as a chromogenic analytical probe for the quantification of amino acids and proteins. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| Target | IC50: chromogenic analytical probe[1] |
| In Vitro | Ninhydrin is used in amino acid analysis of proteins. Except proline, Most amino acids can be hydrolyzed and react with ninhydrin. The amino acids are then quantified colorimetrically after separation by chromatography. Ninhydrin reacts with primary and secondary amines producing a blue or purple reaction product: diketohydrindylidene-diketohydrindamine. |
| References | [1]. Omar MA, et al. Utility of ninhydrin reagent for spectrofluorimetric determination of heptaminol in human plasma.Luminescence. 2018 Sep;33(6):1107-1112. [2]. Anantharaman S, et al. Ninhydrin-sodium molybdate chromogenic analytical probe for the assay of amino acids and proteins.rSpectrochim Acta A Mol Biomol Spectrosc. 2017 Feb 15;173:897-903. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 449.3±45.0 °C at 760 mmHg |
| Melting Point | 250 °C (dec.)(lit.) |
| Molecular Formula | C9H6O4 |
| Molecular Weight | 178.141 |
| Flash Point | 239.7±25.2 °C |
| Exact Mass | 178.026611 |
| PSA | 74.60000 |
| LogP | 1.07 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.737 |
| InChIKey | FEMOMIGRRWSMCU-UHFFFAOYSA-N |
| SMILES | O=C1c2ccccc2C(=O)C1(O)O |
| Storage condition | Store at RT. |
| Stability | Stable. Incompatible with amines, alkalies, strong bases. Light-sensitive. |
| Water Solubility | 0.1-0.5 g/100 mL at 20 ºC |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,28,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 78 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 151,719,1957 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1175 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 594 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1175 No. of Facilities: 476 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 5565 (estimated) No. of Female Employees: 4002 (estimated)
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S28A-S45-S16 |
| RIDADR | UN 1170 3/PG 2 |
| WGK Germany | 3 |
| RTECS | NK5425000 |
| Hazard Class | 3.0 |
| HS Code | 2915900090 |
Customs
| HS Code | 2915900090 |
|---|---|
| Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 2,2-Dihydroxy-1H-indene-1,3(2H)-dione |
| Triketohydrinden Hydrate |
| Ninhydrin |
| 2,2-Dihydroxy-1,3-indanedione |
| Ninhydrin,spectrophotometric grade |
| MFCD00003791 |
| Ninhydrin Spray |
| Ningidrin |
| indane-1,2,3-trione monohydrate |
| NyNhydriN |
| NinhydrinGr |
| 1,2,3-Indanetrione monohydrate |
| Trioxohydrindene monohydrate |
| Ninhydrin,ozone friendly ready to use spray |
| 1H-Indene-1,2,3-trione hydrate |
| Ninhydrin (contains Acetic Acid) Ethanol |
| 1,2,3-Indantrione, 2-hydrate |
| EINECS 207-618-1 |
| NINHYDRINE |
| 1,2,3-triketohydrindene hydrate |
| 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy- |
| 2,2-dihydroxy-2H-indene-1,3-dione |
| Ninhydrin hydrate |
| NinhydrinA.R. |
| NIN |
| Ninthydrin |
| 1,3-Indandione, 2,2-dihydroxy- |
| 1,2,3-Indantrione monohydrate |
| 1,2,3-Indantrione monohydrate,2,2-Dihydroxy-1,3-indanedione,Trioxohydrindene monohydrate |
