CAS 83-07-8|4-Aminoantipyrine

Introduction：Basic information about CAS 83-07-8|4-Aminoantipyrine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 4-Aminoantipyrine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles46
8. Synonyms

Common Name	4-Aminoantipyrine
CAS Number	83-07-8	Molecular Weight	203.240
Density	1.2±0.1 g/cm3	Boiling Point	309.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₃N₃O	Melting Point	105-110 °C(lit.)
MSDS	ChineseUSA	Flash Point	140.7±28.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	4-aminoantipyrine
Synonym	More Synonyms

4-Aminoantipyrine BiologicalActivity

Description	Ampyrone is a reagent for glucose determination in the presence of peroxidase and phenol.
Related Catalog	Research Areas >>Others
Target	COX
References	[1]. Berno CR, et al. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	309.0±45.0 °C at 760 mmHg
Melting Point	105-110 °C(lit.)
Molecular Formula	C₁₁H₁₃N₃O
Molecular Weight	203.240
Flash Point	140.7±28.7 °C
Exact Mass	203.105865
PSA	52.95000
LogP	-0.40
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.607
InChIKey	RLFWWDJHLFCNIJ-UHFFFAOYSA-N
SMILES	Cc1c(N)c(=O)n(-c2ccccc2)n1C
Storage condition	Store at RT.
Stability	Stable. May be light sensitive.
Water Solubility	ca. 500 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CD2480000

CHEMICAL NAME :: Antipyrine, 4-amino-

CAS REGISTRY NUMBER :: 83-07-8

BEILSTEIN REFERENCE NO. :: 0181635

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C11-H13-N3-O

MOLECULAR WEIGHT :: 203.27

WISWESSER LINE NOTATION :: T5NNVJ A1 BR& DZ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 312 ug/well

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82277 No. of Facilities: 114 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 1130 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82277 No. of Facilities: 1080 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 12808 (estimated) No. of Female Employees: 9012 (estimated)

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36-S36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CD2480000
HS Code	29331190

Customs

HS Code	2933199090
Summary	2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles46

Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes.

J. Biol. Chem. 290 , 17879-93, (2015)

Salt-inducible kinases (SIKs), members of the 5'-AMP-activated protein kinase (AMPK) family, are proposed to be important suppressors of gluconeogenic programs in the liver via the phosphorylation-dep...

Cholesterol oxidase with high catalytic activity from Pseudomonas aeruginosa: Screening, molecular genetic analysis, expression and characterization.

J. Biosci. Bioeng. 120 , 24-30, (2015)

An extracellular cholesterol oxidase producer, Pseudomonas aeruginosa strain PA157, was isolated by a screening method to detect 6β-hydroperoxycholest-4-en-3-one-forming cholesterol oxidase. On the ba...

One-touch-activated blood multidiagnostic system using a minimally invasive hollow microneedle integrated with a paper-based sensor.

Lab Chip 15 , 3286-92, (2015)

The development of real-time innocuous blood diagnosis has been a long-standing goal in healthcare; an improved, miniature, all-in-one point-of-care testing (POCT) system with low cost and simplified ...

Synonyms

4-amino-1,5-dimethyl-2-phenylpyrazol-3-one

EINECS 201-452-3

4-Aminoantipyrine

MFCD00003145

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