CAS 2747-05-9|7-Acetoxy-4-methylcoumarin
| Common Name | 7-Acetoxy-4-methylcoumarin | ||
|---|---|---|---|
| CAS Number | 2747-05-9 | Molecular Weight | 218.20500 |
| Density | 1.263g/cm3 | Boiling Point | 371.4ºC at 760mmHg |
| Molecular Formula | C12H10O4 | Melting Point | 149-150 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 191.5ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4-methylumbelliferyl acetate |
|---|---|
| Synonym | More Synonyms |
7-Acetoxy-4-methylcoumarin BiologicalActivity
| Description | 7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>Gutathione S-transferase |
| References | [1]. Feuer, G, et al. Induction of drug-metabolizing enzymes of rat liver by derivatives of coumarin. Canadian Journal of Physiology and Pharmacology, 48(4), 232–240. [2]. Raj HG, et al. Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom. Bioorg Med Chem. 2001 May;9(5):1085-9. |
Chemical & Physical Properties
| Density | 1.263g/cm3 |
|---|---|
| Boiling Point | 371.4ºC at 760mmHg |
| Melting Point | 149-150 °C(lit.) |
| Molecular Formula | C12H10O4 |
| Molecular Weight | 218.20500 |
| Flash Point | 191.5ºC |
| Exact Mass | 218.05800 |
| PSA | 56.51000 |
| LogP | 2.02670 |
| Vapour Pressure | 8.68E-06mmHg at 25°C |
| Index of Refraction | 1.588 |
| InChIKey | HXVZGASCDAGAPS-UHFFFAOYSA-N |
| SMILES | CC(=O)Oc1ccc2c(C)cc(=O)oc2c1 |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2932209090 |
Customs
| HS Code | 2932209090 |
|---|---|
| Summary | 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles21
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| Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J. Med. Chem. 48 , 2906-15, (2005) Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of ... | |
| Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic. Arch. Toxicol. 88(9) , 1681-1694, (2014) Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been develop... |
Synonyms
| 4-Methylumbeliferyl acetate |
| 4-Methylumbelliferyl Acetate |
| 7-Aceoxy-4-MethylcouMarin |
| EINECS 220-386-6 |
| MUB ACETATE |
| acetic acid 4-methyl-2-oxo-2H-chromen-7-yl ester |
| 7-Acetoxy-4-methylcoumarin |
| 7-ACETYL-4-METHYLCOUMARIN |
| MUACETATE |
| 4-METHYL-7-ACETOXYCOUMARIN |
| 4-methyl-2-oxo-2H-chromen-7-yl acetate |
| METHYLUMBELLIFERYL ACETATE |
| 7-acetoxy-4-methyl-chromen-2-one |
| MFCD00006865 |
