CAS 17440-83-4|Amiloride HCl dihydrate
| Common Name | Amiloride HCl dihydrate | ||
|---|---|---|---|
| CAS Number | 17440-83-4 | Molecular Weight | 302.118 |
| Density | / | Boiling Point | 628.1ºC at 760 mmHg |
| Molecular Formula | C6H13Cl2N7O3 | Melting Point | >240℃ |
| MSDS | / | Flash Point | 333.7ºC |
Names
| Name | amiloride hydrochloride dihydrate |
|---|---|
| Synonym | More Synonyms |
Amiloride HCl dihydrate BiologicalActivity
| Description | Amiloride hydrochloride dihydrate is an inhibitor of both Epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease |
| Target | ENaC[1], uTPA[2] |
| In Vivo | Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[1]. |
| Animal Admin | The experiments are performed on male and female Sprague-Dawley rats that have been maintained in a heat controlled room maintained at 23° C with a 12h/12h light-dark schedule. A total of 116 adult rats are injected i.p. with Amiloride hydrochloride dihydrate (0.1, 0.5, and 2.0 mg/kg). After 15, 30, 45, or 120 min post-injection, the rats are anesthetized with 8% chloral hydrate, the chest is opened, and blood samples are obtained by cardiac puncture. The blood is centrifuged at 5000 RPM for 5 min, and the plasma (1.5 mL) separated and stored at -80° C[1]. |
| References | [1]. Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. [2]. Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29. |
Chemical & Physical Properties
| Boiling Point | 628.1ºC at 760 mmHg |
|---|---|
| Melting Point | >240℃ |
| Molecular Formula | C6H13Cl2N7O3 |
| Molecular Weight | 302.118 |
| Flash Point | 333.7ºC |
| Exact Mass | 301.045685 |
| PSA | 175.25000 |
| LogP | 1.94440 |
| Vapour Pressure | 1.08E-15mmHg at 25°C |
| InChIKey | LTKVFMLMEYCWMK-UHFFFAOYSA-N |
| SMILES | Cl.NC(N)=NC(=O)c1nc(Cl)c(N)nc1N.O.O |
| Storage condition | -20°C |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2933599090 |
Customs
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Modamide |
| Amiloride hydrochloride dihydrate |
| AMILORIDEHYDROCHLORIDE,USP |
| UNII-FZJ37245UC |
| 3,5-Diamino-N-carbamimidoyl-6-chloro-2-pyrazinecarboxamide hydrochloride dihydrate |
| Midamor |
| Miloride hydrochloride dihydrate |
| AMILORIDE HYDROCHLORIDE 2-HYDRATE |
| 2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, hydrochloride, hydrate (1:1:2) |
| AMILORIDE HCL DIHYDRATE |
