CAS 201677-61-4|Sivelestat Sodium tetrahydrate

Introduction：Basic information about CAS 201677-61-4|Sivelestat Sodium tetrahydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sivelestat Sodium tetrahydrate BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Sivelestat Sodium tetrahydrate
CAS Number	201677-61-4	Molecular Weight	528.506
Density	/	Boiling Point	/
Molecular Formula	C₂₀H₂₉N₂NaO₁₁S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate,tetrahydrate
Synonym	More Synonyms

Sivelestat Sodium tetrahydrate BiologicalActivity

Description	Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.IC50 value: 44 nM [1]Target: neutrophil elastaseONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>ElastaseResearch Areas >>Others
References	[1]. Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20. [2]. Imokawa S, et al. Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate. Nihon Kokyuki Gakkai Zasshi. 2008 Jun;46(6):461-5.

Description

Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.IC50 value: 44 nM [1]Target: neutrophil elastaseONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2].

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>ElastaseResearch Areas >>Others

References

[1]. Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.

[2]. Imokawa S, et al. Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate. Nihon Kokyuki Gakkai Zasshi. 2008 Jun;46(6):461-5.

Chemical & Physical Properties

Molecular Formula	C₂₀H₂₉N₂NaO₁₁S
Molecular Weight	528.506
Exact Mass	528.138977
PSA	187.00000
LogP	2.20610
InChIKey	PLHREJBSQUSUCW-UHFFFAOYSA-M
SMILES	CC(C)(C)C(=O)Oc1ccc(S(=O)(=O)Nc2ccccc2C(=O)NCC(=O)[O-])cc1.O.O.O.O.[Na+]
Storage condition	-20℃

Synonyms

Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt, hydrate (1:1:4)

Sivelestat sodium hydrate

Sivelestat Sodium

Sivelestat sodium tetrahydrate

Elaspol

ONO-5046.Na

(N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycinato-κO)sodium tetrahydrate

Sodium ({2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}amino)acetate hydrate (1:1:4)

sodium, [2,2-dimethylpropanoato, 4-[[[2-[[[(carboxy-κO)methyl]amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester]-, hydrate (1:4)

MFCD01937969

UNII-737RR8Y409

Sivelestat (sodium tetrahydrate)

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