Introduction：Basic information about CAS 7411-12-3|Formamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl], including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Formamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- |
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| CAS Number | 7411-12-3 | Molecular Weight | 385.41000 |
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| Density | 1.27g/cm3 | Boiling Point | 715.8ºC at 760 mmHg |
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| Molecular Formula | C21H23NO6 | Melting Point | 264-267ºC |
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| MSDS | / | Flash Point | 386.7ºC |
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Names
| Name | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 1.27g/cm3 |
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| Boiling Point | 715.8ºC at 760 mmHg |
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| Melting Point | 264-267ºC |
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| Molecular Formula | C21H23NO6 |
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| Molecular Weight | 385.41000 |
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| Flash Point | 386.7ºC |
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| Exact Mass | 385.15300 |
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| PSA | 83.09000 |
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| LogP | 3.50830 |
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| Index of Refraction | 1.591 |
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| InChIKey | HDSXDWASQCHADG-HNNXBMFYSA-N |
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| SMILES | COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1C(NC=O)CC2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GH0794000
- CHEMICAL NAME :
- Colchicine, N-deacetyl-N-formyl-
- CAS REGISTRY NUMBER :
- 7411-12-3
- BEILSTEIN REFERENCE NO. :
- 2824080
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C21-H23-N-O6
- MOLECULAR WEIGHT :
- 385.45
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMVH NO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 33,1606,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4400 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2666 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9200 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
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Safety Information
Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| Formyldescaetylcolchicine,N |
| N-deacetyl-N-formylcolchicine |
| N-Formyldeacetylcolchicine |
| N-Desacetyl-N-formyl-colchicin |
| COLCHICINE,N-DEACETYL-N-FORMYL |
| N-((S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamid |
| Gloriosine |
| N-formyl-N-deacetylcolchicine |
| N-Formyldesacetylcolchicine |
| (S)-7-Formylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on |
| N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamide |
