Introduction：Basic information about CAS 2373-89-9|2-Propen-1-one,1,3-bis(4-methoxyphenyl)-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Propen-1-one,1,3-bis(4-methoxyphenyl)- |
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| CAS Number | 2373-89-9 | Molecular Weight | 268.30700 |
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| Density | 1.128g/cm3 | Boiling Point | 444.6ºC at 760 mmHg |
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| Molecular Formula | C17H16O3 | Melting Point | 101°C |
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| MSDS | / | Flash Point | 214.6ºC |
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Names
| Name | 4,4'-dimethoxychalcone |
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| Synonym | More Synonyms |
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2-Propen-1-one,1,3-bis(4-methoxyphenyl)- BiologicalActivity
| Description | 4,4'-Dimethoxychalcone, isolated from the plant Angelica keiskei koidzumi, acts as a natural autophagy inducer with anti-ageing properties[1]. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Metabolic Disease |
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| Target | Autophagy[1] |
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| In Vivo | The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species[1]. 4,4'-Dimethoxychalcone (100 mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice[1]. Animal Model: 6-week-old male wild type C57BL/6 or Atg4b-/- mice[1] Dosage: 100 mg/kg Administration: Injected intraperitoneally with a single Result: Triggered autophagic flux in the heart and liver. |
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| References | [1]. Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. |
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Chemical & Physical Properties
| Density | 1.128g/cm3 |
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| Boiling Point | 444.6ºC at 760 mmHg |
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| Melting Point | 101°C |
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| Molecular Formula | C17H16O3 |
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| Molecular Weight | 268.30700 |
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| Flash Point | 214.6ºC |
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| Exact Mass | 268.11000 |
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| PSA | 35.53000 |
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| LogP | 3.59990 |
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| Vapour Pressure | 4.23E-08mmHg at 25°C |
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| Index of Refraction | 1.591 |
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Safety Information
| Hazard Codes | N |
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| Risk Phrases | R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . |
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| Safety Phrases | S61 |
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| RIDADR | UN 3082 9/PG 3 |
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| WGK Germany | 3 |
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| HS Code | 2914509090 |
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| MFCD00025815 |
| 4,4'-DIMETHOXYBENZYLIDENEACETOPHENONE |
| DIMETHOXYCHALCONE,4,4'-(RG) |
| 4,4'-dimethoxy-chalcone |
| 1,3-bis-{4-methoxy-phenyl}-propen-(1)-one-(3) |
| 1,3-bis-(4-methoxyphenyl)-propenone |
| 2-Propen-1-one,1,3-bis(4-methoxyphenyl) |
| 1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE |
| (E)-1,3-BIS(4-METHOXYPHENYL)PROP-2-EN-1-ONE |
| DIMETHOXYCHALCONE,4,4' |
| 4,4'-Dimethoxy-chalkon |
