CAS 106-31-0|Butanoic anhydride

Introduction：Basic information about CAS 106-31-0|Butanoic anhydride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles4
7. Synonyms

Common Name	Butanoic anhydride
CAS Number	106-31-0	Molecular Weight	158.195
Density	1.0±0.1 g/cm3	Boiling Point	198.3±8.0 °C at 760 mmHg
Molecular Formula	C₈H₁₄O₃	Melting Point	−75-−66 °C(lit.)
MSDS	ChineseUSA	Flash Point	87.8±0.0 °C
Symbol	GHS05	Signal Word	Danger

Names

Name	Butyric anhydride
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	198.3±8.0 °C at 760 mmHg
Melting Point	−75-−66 °C(lit.)
Molecular Formula	C₈H₁₄O₃
Molecular Weight	158.195
Flash Point	87.8±0.0 °C
Exact Mass	158.094299
PSA	43.37000
LogP	1.64
Vapour density	5.45 (vs air)
Vapour Pressure	0.4±0.4 mmHg at 25°C
Index of Refraction	1.421
InChIKey	YHASWHZGWUONAO-UHFFFAOYSA-N
SMILES	CCCC(=O)OC(=O)CCC
Water Solubility	Decomposes

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ET7090000

CHEMICAL NAME :: Butyric anhydride

CAS REGISTRY NUMBER :: 106-31-0

BEILSTEIN REFERENCE NO. :: 1099474

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H14-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,321,1986

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >50 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >50 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 4,29,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 30 mg/m3/2H/30D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 3,48,1961 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5716 No. of Facilities: 25 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 4817 (estimated) No. of Female Employees: 755 (estimated)

Safety Information

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H314
Supplemental HS	Reacts violently with water.
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C:Corrosive;
Risk Phrases	R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2739 8/PG 3
WGK Germany	1
RTECS	ET7090000
Packaging Group	III
Hazard Class	8
HS Code	2915900090

Customs

HS Code	2915900090
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles4

Synthesis and Characterization of a Novel Phenolic Lipid for Use as Potential Lipophilic Antioxidant and as a Prodrug of Butyric Acid.

J. Oleo Sci. 64 , 845-52, (2015)

Ferulic acid was modified to produce a novel phenolipid containing butyl chains. Ferulic acid was esterified with butanol to produce butyl ferulate which was further dihydroxylated followed by esterif...

Evaluation of dibutyrylchitin as new excipient for sustained drug release.

Drug Dev. Ind. Pharm. 38(8) , 979-84, (2012)

Dibutyrylchitin (DBC), a lipophilic chitin diester, has been synthesized from chitin and butyric anhydride with methanesulfonic acid as catalyst. Exhaustive esterification of free alcoholic groups of ...

Hyaluronic acid as drug delivery for sodium butyrate: improvement of the anti-proliferative activity on a breast-cancer cell line.

Int. J. Cancer 81(3) , 411-6, (1999)

The potential clinical utility of sodium butyrate, a natural compound known to inhibit tumor-cell growth, is hampered by the difficulty of achieving effective in-vivo concentrations. The short half-li...

Synonyms

Butanoic anhydride

Butyric Anhydride

N-Butyric Anhydride

EINECS 203-383-4

MFCD00009389

butanoyl butanoate

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