CAS 17954-98-2|22-alpha-Hydroxy Cholesterol
| Common Name | 22-alpha-Hydroxy Cholesterol | ||
|---|---|---|---|
| CAS Number | 17954-98-2 | Molecular Weight | 402.65 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 513.1±23.0 °C at 760 mmHg |
| Molecular Formula | C27H46O2 | Melting Point | / |
| MSDS | USA | Flash Point | 213.5±17.2 °C |
Names
| Name | (22R)-22-hydroxycholesterol |
|---|---|
| Synonym | More Synonyms |
22-alpha-Hydroxy Cholesterol BiologicalActivity
| Description | 22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>LXRResearch Areas >>Metabolic Disease |
| References | [1]. Costet P, et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000 Sep 8;275(36):28240-5. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.1±23.0 °C at 760 mmHg |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.65 |
| Flash Point | 213.5±17.2 °C |
| Exact Mass | 402.349792 |
| PSA | 40.46000 |
| LogP | 7.66 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | RZPAXNJLEKLXNO-GFKLAVDKSA-N |
| SMILES | CC(C)CCC(O)C(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles48
More Articles| Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells. Gynecol. Oncol. 135(2) , 333-41, (2014) Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxys... | |
| HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells. Toxicol. Appl. Pharmacol. 282(1) , 20-9, (2015) Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD distu... | |
| Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout. Biol. Reprod. 86(1) , 1-12, (2012) In fish, like in other vertebrates, luteinizing hormone (Lh) is an essential hormone for the completion of oocyte maturation. In salmonid fish (i.e., salmon and trout), oocyte maturation is induced by... |
Synonyms
| Narthesterol |
| 22BF-HYDROXYCHOLESTEROL |
| 22(S)-hydroxycholesterol |
| (3β,22S)-Cholest-5-ene-3,22-diol |
| 22BETA-HYDROXYCHOLESTEROL |
| Cholest-5-ene-3,22-diol, (3β,22S)- |
| 22R-OHC |
| 22(R)-HYDROXYCHOLESTEROL |
