Introduction：Basic information about CAS 6061-96-7|2-Methylcitric acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Methylcitric acid |
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| CAS Number | 6061-96-7 | Molecular Weight | 206.15000 |
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| Density | 1.178g/cm3 | Boiling Point | 464.4ºC at 760 mmHg |
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| Molecular Formula | C7H10O7 | Melting Point | 79°C (lit.) |
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| MSDS | / | Flash Point | 234.7ºC |
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Names
| Name | 2-methylcitric acid |
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| Synonym | More Synonyms |
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2-Methylcitric acid BiologicalActivity
| Description | 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1]. |
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| Related Catalog | Research Areas >>Metabolic Disease |
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| Target | Human Endogenous Metabolite |
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| In Vitro | 2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1]. 2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1]. 2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria[1]. |
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| References | [1]. Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185(9):2802-10. |
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Chemical & Physical Properties
| Density | 1.178g/cm3 |
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| Boiling Point | 464.4ºC at 760 mmHg |
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| Melting Point | 79°C (lit.) |
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| Molecular Formula | C7H10O7 |
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| Molecular Weight | 206.15000 |
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| Flash Point | 234.7ºC |
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| Exact Mass | 206.04300 |
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| PSA | 132.13000 |
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| Index of Refraction | 1.586 |
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| InChIKey | YNOXCRMFGMSKIJ-UHFFFAOYSA-N |
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| SMILES | CC(C(=O)O)C(O)(CC(=O)O)C(=O)O |
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Safety Information
Customs
| HS Code | 2918199090 |
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| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| 2-hydroxy-butane-1,2,3-tricarboxylic acid |
| 1,2,3-Butanetricarboxylic acid,2-hydroxy |
| 2-Hydroxy-butan-1,2,3-tricarbonsaeure |
| 2-hydroxybutane-1,2,3-tricarboxylate |
| 2-methylcitrate |
| 2-hydroxy-1,2,3-butantricarbons |
| Methylcitronensaeure |
| 2-hydroxybutane-1,2,3-tricarboxylic acid |
| 2-hydroxy-1,2,3-butanetricarboxylic acid |
| 2-Methylcitric acid |
