Introduction：Basic information about CAS 622-08-2|2-(Benzyloxy)ethanol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-(Benzyloxy)ethanol |
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| CAS Number | 622-08-2 | Molecular Weight | 152.190 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 254.4±15.0 °C at 760 mmHg |
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| Molecular Formula | C9H12O2 | Melting Point | <-75ºC |
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| MSDS | ChineseUSA | Flash Point | 108.0±14.6 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 2-Benzyloxyethanol |
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| Synonym | More Synonyms |
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2-(Benzyloxy)ethanol BiologicalActivity
| Description | 2-(Benzyloxy)ethanol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Reed NN, et al. A one-step synthesis of monoprotected polyethylene glycol ethers. J Org Chem. 2000 Sep 8;65(18):5843-5. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 254.4±15.0 °C at 760 mmHg |
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| Melting Point | <-75ºC |
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| Molecular Formula | C9H12O2 |
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| Molecular Weight | 152.190 |
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| Flash Point | 108.0±14.6 °C |
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| Exact Mass | 152.083725 |
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| PSA | 29.46000 |
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| LogP | 1.38 |
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| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
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| Index of Refraction | 1.525 |
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| InChIKey | CUZKCNWZBXLAJX-UHFFFAOYSA-N |
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| SMILES | OCCOCc1ccccc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- KJ7550000
- CHEMICAL NAME :
- Ethanol, 2-(benzyloxy)-
- CAS REGISTRY NUMBER :
- 622-08-2
- BEILSTEIN REFERENCE NO. :
- 2043566
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C9-H12-O2
- MOLECULAR WEIGHT :
- 152.21
- WISWESSER LINE NOTATION :
- Q2O1R
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1190 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302-H315-H319-H335 |
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| Precautionary Statements | P261-P305 + P351 + P338 |
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| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
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| Hazard Codes | Xn:Harmful; |
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| Risk Phrases | R22;R36/37/38 |
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| Safety Phrases | S26-S36-S37/39 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | KJ7550000 |
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| HS Code | 2909499000 |
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Customs
| HS Code | 2909499000 |
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| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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| A structure-based library approach to kinase inhibitors. Norman TC, et al. J. Am. Chem. Soc. 118(31) , 7430-31, (1996)
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| Poly (benzyloxy ethyl methacrylate): preparation by free radical polymerization and by group transfer polymerization; with subsequent debenzylation to form poly (2-hydroxyethyl methacrylate). Dyakonov TA, et al. Eur. Polymer J. 36(9) , 1779-93, (2000)
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Synonyms
| 2-(Benzyloxy)ethanol |
| Ethanol, 2- (benzyloxy)- |
| 2-(Benzyl-Oxy)Ethan-1-Ol |
| MFCD00002868 |
| 2-phenylmethoxyethanol |
| Benzyl cellosolve |
| Ethanol, 2-(phenylmethoxy)- |
| Glycol benzyl ether |
| UNII-06S8147L47 |
| EINECS 210-719-3 |
| ethylene glycol monobenzyl ether |
| Ethanol, 2- (phenylmethoxy)- |
