CAS 108-31-6|Maleic anhydride
Introduction：Basic information about CAS 108-31-6|Maleic anhydride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Maleic anhydride | ||
|---|---|---|---|
| CAS Number | 108-31-6 | Molecular Weight | 98.057 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 202.0±0.0 °C at 760 mmHg |
| Molecular Formula | C4H2O3 | Melting Point | 51-56 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 103.3±0.0 °C |
| Symbol | GHS05, GHS07, GHS08 | Signal Word | Danger |
Names
| Name | maleic anhydride |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 202.0±0.0 °C at 760 mmHg |
| Melting Point | 51-56 °C(lit.) |
| Molecular Formula | C4H2O3 |
| Molecular Weight | 98.057 |
| Flash Point | 103.3±0.0 °C |
| Exact Mass | 98.000397 |
| PSA | 43.37000 |
| LogP | -0.37 |
| Vapour density | 3.4 (vs air) |
| Vapour Pressure | 0.3±0.4 mmHg at 25°C |
| Index of Refraction | 1.515 |
| InChIKey | FPYJFEHAWHCUMM-UHFFFAOYSA-N |
| SMILES | O=C1C=CC(=O)O1 |
| Stability | Stable. Combustible. Incompatible with water, strong oxidizing agents, alkali metals, strong bases, amines, most common metals, polymerization catalysts and accelerators. |
| Water Solubility | 79 g/100 mL (25 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 97 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 465 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 875 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2620 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9800 ug/m3/6H/26W-I
- TOXIC EFFECTS :
- Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1220 mg/kg/61W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4060 mg/kg
- SEX/DURATION :
- multigenerations
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- REFERENCE :
- GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** ACGIH TLV-TWA 1.0 mg/m3 (0.25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.25 ppm (1 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,148,1971 OSHA PEL (Gen Indu):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.25 ppm (1 mg/m3);STEL 0.75 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 1 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.3 ppm (1.2 mg/m3);STEL 0.6 ppm (2.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (0.8 mg/m3);STEL 0.4 ppm (1.6 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MALEIC ANHYDRIDE-air:10H TWA 0.25 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 43660 No. of Facilities: 5310 (estimated) No. of Industries: 51 No. of Occupations: 69 No. of Employees: 71386 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 43660 No. of Facilities: 5924 (estimated) No. of Industries: 65 No. of Occupations: 69 No. of Employees: 81551 (estimated) No. of Female Employees: 14807 (estimated)
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- REFERENCE :
- GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** ACGIH TLV-TWA 1.0 mg/m3 (0.25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,250,1970 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.25 ppm (1 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,148,1971 OSHA PEL (Gen Indu):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.25 ppm CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.25 ppm (1 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.25 ppm (1 mg/m3);STEL 0.75 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 1 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWEDEN:TWA 0.3 ppm (1.2 mg/m3);STEL 0.6 ppm (2.5 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (0.8 mg/m3);STEL 0.4 ppm (1.6 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.25 ppm (1 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MALEIC ANHYDRIDE-air:10H TWA 0.25 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 43660 No. of Facilities: 5310 (estimated) No. of Industries: 51 No. of Occupations: 69 No. of Employees: 71386 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 43660 No. of Facilities: 5924 (estimated) No. of Industries: 65 No. of Occupations: 69 No. of Employees: 81551 (estimated) No. of Female Employees: 14807 (estimated)
Safety Information
| Symbol | GHS05, GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H314-H317-H334-H372-H373 |
| Supplemental HS | Corrosive to the respiratory tract. |
| Precautionary Statements | P261-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P342 + P311 |
| Target Organs | Kidney, Respiratory system |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | C:Corrosive |
| Risk Phrases | R22;R34;R42/43 |
| Safety Phrases | S22-S26-S36/37/39-S45 |
| RIDADR | UN 2215 8/PG 3 |
| WGK Germany | 1 |
| RTECS | ON3675000 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2917140000 |
Customs
| HS Code | 2917140000 |
|---|---|
| Summary | 2917140000 furan-2,5-dione。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0% |
Articles28
More Articles| An Oligonucleotide Transfection Vector Based on HSA and PDMAEMA Conjugation: Effect of Polymer Molecular Weight on Cell Proliferation and on Multicellular Tumor Spheroids. Macromol. Biosci. 15 , 965-78, (2015) A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end functionalized poly[(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA). The bioco... | |
| Extracellular matrix deposition of bone marrow stroma enhanced by macromolecular crowding. Biomaterials 73 , 60-9, (2015) Decellularized extracellular matrices (ECM) from in vitro cell cultures can serve as in vivo-like matrix scaffolds for modulating cell-ECM interactions. Macromolecular crowding (MMC), the supplementat... | |
| Self-cleaning Metal Organic Framework (MOF) based ultra filtration membranes--a solution to bio-fouling in membrane separation processes. Sci. Rep. 4 , 6555, (2014) Bio-fouling is a serious problem in many membrane-based separation processes for water and wastewater treatment. Current state of the art methods to overcome this are to modify the membranes with eith... |
Synonyms
| Toxilic anhydride |
| BM-10 |
| MFCD00005518 |
| Maleic |
| Maleic anhydride |
| EINECS 203-571-6 |
| dihydro-2,5-dioxofuran |
| 2,5-Furandione |
| Furan-2,5-Dione |
| maleic acid anhydride |
| mala |
| MAN |
| Lytron 820 |
