Introduction：Basic information about CAS 22338-71-2|Virgaureagenin G, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Virgaureagenin G |
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| CAS Number | 22338-71-2 | Molecular Weight | 504.698 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 638.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C30H48O6 | Melting Point | 315-318ºC |
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| MSDS | / | Flash Point | 353.7±28.0 °C |
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Names
| Name | Polygalacic acid |
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| Synonym | More Synonyms |
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Virgaureagenin G BiologicalActivity
| Description | Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment [1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex[2]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>MMPResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
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| In Vitro | Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1]. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1]. RT-PCR[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 24 hours Result: Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. Western Blot Analysis[1] Cell Line: Chondrocyte cells Concentration: 50 μM; 100 μM Incubation Time: 6 hours Result: Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |
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| References | [1]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252. [2]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23(2):149-55. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 638.1±55.0 °C at 760 mmHg |
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| Melting Point | 315-318ºC |
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| Molecular Formula | C30H48O6 |
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| Molecular Weight | 504.698 |
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| Flash Point | 353.7±28.0 °C |
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| Exact Mass | 504.345093 |
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| PSA | 118.22000 |
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| LogP | 5.03 |
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| Vapour Pressure | 0.0±4.3 mmHg at 25°C |
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| Index of Refraction | 1.593 |
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| InChIKey | KGGGRGBDMBZXKF-YQJGEOIASA-N |
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| SMILES | CC1(C)CCC2(C(=O)O)C(O)CC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5CCC43C)C2C1 |
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Safety Information
Synonyms
| (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid |
| Polygalacic |
| Polygalacicacid |
| Virgaureagenin G |
| (2β,3β,5ξ,16α,18α)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid |
| Vigaureagenin G |
| Olean-12-en-28-oic acid, 2,3,16,23-tetrahydroxy-, (2β,3β,5ξ,16α,18α)- |
| Polygalac Saeure |
