CAS 464-45-9|(-)-Borneol
Introduction：Basic information about CAS 464-45-9|(-)-Borneol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (-)-Borneol | ||
|---|---|---|---|
| CAS Number | 464-45-9 | Molecular Weight | 154.249 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 212.0±0.0 °C at 760 mmHg |
| Molecular Formula | C10H18O | Melting Point | 206-209 °C |
| MSDS | ChineseUSA | Flash Point | 65.6±0.0 °C |
| Symbol | GHS02, GHS07 | Signal Word | Warning |
Names
| Name | (-)-borneol |
|---|---|
| Synonym | More Synonyms |
(-)-Borneol BiologicalActivity
| Description | (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorSignaling Pathways >>Neuronal Signaling >>GABA ReceptorResearch Areas >>Neurological DiseaseNatural Products >>Terpenoids and Glycosides |
| Target | EC50: 237 μM (GABA receptor)[1] |
| In Vitro | (-)-Borneol is an enantiomer of (+)-Borneol. (+)-Borneol is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. At high concentrations (>1.5 mM), (-)-Borneol directly activates GABAA receptors producing 84% of the maximal GABA response indicative of a weak partial agonist action. (-)-Borneol produces dose-dependent positive modulation of the Cl- conductance generated by extremely low dose GABA at α1β2γ2L GABAA receptors[1]. |
| References | [1]. IGranger RE, et al. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 212.0±0.0 °C at 760 mmHg |
| Melting Point | 206-209 °C |
| Molecular Formula | C10H18O |
| Molecular Weight | 154.249 |
| Flash Point | 65.6±0.0 °C |
| Exact Mass | 154.135757 |
| PSA | 20.23000 |
| LogP | 2.71 |
| Vapour density | 5.31 (vs air) |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.502 |
| Water Solubility | INSOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,655,1978 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,655,1978
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H228-H317 |
| Precautionary Statements | P210-P280 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | F:Flammable; |
| Risk Phrases | R11 |
| Safety Phrases | S16-S36/37 |
| RIDADR | UN 1312 4.1/PG 3 |
| WGK Germany | 2 |
| RTECS | DT5095000 |
| Packaging Group | III |
| Hazard Class | 4.1 |
| HS Code | 29061900 |
Customs
| HS Code | 2906199090 |
|---|---|
| Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
Articles30
More Articles| Kinetics and mechanisms of the tropospheric reactions of menthol, borneol, fenchol, camphor, and fenchone with hydroxyl radicals (OH) and chlorine atoms (Cl). J. Phys. Chem. A 116(16) , 4097-107, (2012) Relative kinetic techniques have been used to measure the rate coefficients for the reactions of oxygenated terpenes (menthol, borneol, fenchol, camphor, and fenchone) and cyclohexanol with hydroxyl r... | |
| Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation 20(1) , 17-29, (2013) The present study was designed to evaluate whether CP was beneficial in alleviating myocardial fibrosis following I/R injury.Sprague-Dawley rats were subjected to 30 minutes occlusion of the LADCA, fo... | |
| Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells. Pharm. Biol. 51(1) , 30-5, (2013) The β-amyloid (Aβ) peptide aggregation with accompanying oxidative stress plays the major role in the pathogenesis of Alzheimer's disease (AD). Some natural compounds, including borneol, shed promisin... |
Synonyms
| L-BORNEOL |
| l-2-Bornanol |
| Borneol |
| endo-(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol |
| endo-2-hydroxycamphane |
| 2-Camphanol |
| Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S-endo)- |
| L(-)-Borneol |
| Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S,2R,4S)- |
| (1S,2R,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol |
| [(1s)-endo]-(-)-borneol |
| 2-Bornanol, endo- |
| EINECS 207-353-1 |
| (1S-endo)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol |
| (-)-Borneol |
| (−)-Borneol |
| Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1S,2R,4S)- |
| FEMA 2157 |
| (1S)-endo-(-)-Borneol |
| BICYCLO(2.2.1)HEPTAN-2-OL, 1,7,7-TRIMETHYL-, (1S-ENDO)- |
| 2-bornanol |
| Bornan-2-ol |
| MFCD00003759 |
| (？)-Borneol |
| endo-2-Bornanol |
| Linderol |
| endo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol |
| Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, endo- |
| endo-2-camphanol |
| ngaicamphor |
| bornel |
