Introduction：Basic information about CAS 69123-98-4|Fialuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fialuridine |
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| CAS Number | 69123-98-4 | Molecular Weight | 372.09 |
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| Density | 2.2±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H10FIN2O5 | Melting Point | 216-217ºC |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil |
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| Synonym | More Synonyms |
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Fialuridine BiologicalActivity
| Description | Fialuridine is a nucleoside analog with antiviral activity[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
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| References | [1]. Mansuri MM, et al. 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly selective antiherpes simplex agent. J Med Chem. 1987 May;30(5):867-71. |
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Chemical & Physical Properties
| Density | 2.2±0.1 g/cm3 |
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| Melting Point | 216-217ºC |
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| Molecular Formula | C9H10FIN2O5 |
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| Molecular Weight | 372.09 |
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| Exact Mass | 371.961823 |
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| PSA | 104.55000 |
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| LogP | -0.32 |
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| Index of Refraction | 1.685 |
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| InChIKey | IPVFGAYTKQKGBM-BYPJNBLXSA-N |
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| SMILES | O=c1[nH]c(=O)n(C2OC(CO)C(O)C2F)cc1I |
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| Storage condition | Refrigerator |
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| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YQ9512500
- CHEMICAL NAME :
- Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-
- CAS REGISTRY NUMBER :
- 69123-98-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H10-F-I-N2-O5
- MOLECULAR WEIGHT :
- 372.11
- WISWESSER LINE NOTATION :
- T6NVMVJ EI A- BT5OTJ CF DQ E1Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 9100 ug/kg/13W-I
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified Liver - liver function tests impaired Nutritional and Gross Metabolic - metabolic acidosis
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 40 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3957,1982
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Safety Information
| Hazard Codes | Xi |
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| Safety Phrases | 24/25 |
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| RIDADR | NONH for all modes of transport |
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| RTECS | YQ9512500 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles27
More Articles
| Improved synthesis of 2'-deoxy-2'-[18F]-fluoro-1-beta-D-arabinofuranosyl-5-iodouracil ([18F]-FIAU). Nucl. Med. Biol. 37(4) , 439-42, (2010) An improved synthesis of 2'-[(18)F]-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodouracil ([(18)F]-FIAU) has been developed. The method utilizes trimethylsilyl trifluoromethanesulfonate (TMSOTf) cata... | |
| Imaging of a localized bacterial infection with endogenous thymidine kinase using radioisotope-labeled nucleosides. Int. J. Med. Microbiol. 302(2) , 101-7, (2012) The importance of noninvasive imaging methods to bacterial infections is widely recognized. To obtain bacterial infection imaging with radioisotope-labeled nucleosides, bacterial thymidine kinase (tk)... | |
| Enhanced antitumor effects by combination gene therapy using MDR1 gene shRNA and HSV1-tk in a xenograft mouse model. Cancer Lett. 291(1) , 83-9, (2010) The use of a novel therapeutic vector containing HSV1-thymidine kinase (HSV1-tk) and a short hairpin RNA for the MDR1 gene (shMDR) was proposed previously. We investigated the antitumor effects in an ... | |
Synonyms
| 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil |
| 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione |
| 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione |
| 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione |
| Fialuridine |
| 5-Iodo-2'-fluoroarauracil |
| 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodopyrimidine-2,4(1H,3H)-dione |
| 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo- |
| 2'-Deoxy-2'-fluoro-5-iodouridine |
| 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione |
| 1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodouracil |
| 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo- |
