CAS 1166-52-5|Dodecyl gallate
Introduction：Basic information about CAS 1166-52-5|Dodecyl gallate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dodecyl gallate | ||
|---|---|---|---|
| CAS Number | 1166-52-5 | Molecular Weight | 338.439 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 521.7±45.0 °C at 760 mmHg |
| Molecular Formula | C19H30O5 | Melting Point | 94-97 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 180.3±22.2 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Dodecyl gallate |
|---|---|
| Synonym | More Synonyms |
Dodecyl gallate BiologicalActivity
| Description | Dodecyl gallate (Lauryl gallate) has been widely used as an antioxidant in food manufacturing, as well as in the pharmaceutical and cosmetic industries. Dodecyl gallate also is active against a highly relevant animal virus such as African swine fever virus (ASFV)[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Others >>Others |
| In Vitro | Dodecyl gallate (Lauryl gallate) is an ester derivative of gallic acid, a natural plant phenolic compound. Dodecyl gallate (Lauryl gallate) protects cells from oxidative stress, in a process associated with radical scavenging, inhibition of enzymes involved in lipid peroxidation, and increasing expression of antioxidant genes. Due to its hydrophobic properties, Dodecyl gallate can disrupt biomembranes and cause protein inactivation[1]. |
| References | [1]. Patricia de León, et al. Inhibition of Porcine Viruses by Different Cell-Targeted Antiviral Drugs. Front Microbiol. 2019 Aug 14;10:1853. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 521.7±45.0 °C at 760 mmHg |
| Melting Point | 94-97 °C(lit.) |
| Molecular Formula | C19H30O5 |
| Molecular Weight | 338.439 |
| Flash Point | 180.3±22.2 °C |
| Exact Mass | 338.209320 |
| PSA | 86.99000 |
| LogP | 7.38 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.535 |
| InChIKey | RPWFJAMTCNSJKK-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCOC(=O)c1cc(O)c(O)c(O)c1 |
| Storage condition | 0-6°C |
| Water Solubility | practically insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 38A,22,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 135 gm/kg/32W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 28,304,1951
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75 gm/kg/10D-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Related to Chronic Data - death
- REFERENCE :
- JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 28,304,1951
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R43 |
| Safety Phrases | S24-S37 |
| RIDADR | 3335 |
| WGK Germany | 1 |
| RTECS | DH9100000 |
| HS Code | 29182950 |
Customs
| HS Code | 2918290000 |
|---|---|
| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
Articles29
More Articles| Apolar Radical Initiated Conjugated Autoxidizable Triene (ApoCAT) Assay: Effects of Oxidant Locations on Antioxidant Capacities and Interactions. J. Agric. Food Chem. 63 , 7546-55, (2015) Development of an antioxidant assay explaining antioxidant behaviors in complex food systems has been a challenging topic for food scientists. This research aimed to investigate antioxidant capacities... | |
| Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi. Bioorg. Med. Chem. Lett. 19 , 1793-6, (2009) The antifungal activity of a complete series of 15 n-alkyl gallates and six analogues acting against a representative panel of opportunistic pathogenic fungi was studied in order to analyze their role... | |
| The sensitizing capacity of the antioxidants propyl, octyl, and dodecyl gallate and some related gallic acid esters. Contact Dermatitis 26(4) , 253-8, (1992) 8 alkyl gallates, including the widely used antioxidants propyl, octyl, and dodecyl (= lauryl) gallate, have been subjected to experimental sensitization in guinea pigs. Using a modern sensitization p... |
Synonyms
| 3,4,5-trihydroxy-benzoic acid dodecyl ester |
| Nipagallin LA |
| 3mg/kg |
| dodecyl3,4,5 |
| Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester |
| Dodecyl gallate |
| E312 |
| MFCD00002195 |
| Lauryl gallate |
| Gallic acid, lauryl ester |
| lauryl 3,4,5-trihydroxybenzoate |
| Dodecyl 3,4,5-trihydroxybenzoate |
| Gallic acid, dodecyl ester (8CI) |
| Gallic acid n-dodecyl ester |
| Gallic Acid Lauryl Ester |
| n-dodecyl gallate |
| Progallin LA |
| Gallic acid, dodecyl ester |
| Gallic Acid Dodecyl Ester |
| EINECS 214-620-6 |
