Introduction：Basic information about CAS 1083-57-4|Bucetin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bucetin |
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| CAS Number | 1083-57-4 | Molecular Weight | 223.26800 |
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| Density | 1.151g/cm3 | Boiling Point | 433.5ºC at 760 mmHg |
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| Molecular Formula | C12H17NO3 | Melting Point | 160ºC |
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| MSDS | ChineseUSA | Flash Point | 216ºC |
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| Symbol |
GHS07, GHS08 | Signal Word | Danger |
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Names
| Name | 3-hydroxy-p-butyrophenetidine |
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| Synonym | More Synonyms |
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Bucetin BiologicalActivity
| Description | Bucetin (3-Hydroxy-p-butyrophenetidide) is an analgesic and antipyretic compound. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
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Chemical & Physical Properties
| Density | 1.151g/cm3 |
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| Boiling Point | 433.5ºC at 760 mmHg |
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| Melting Point | 160ºC |
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| Molecular Formula | C12H17NO3 |
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| Molecular Weight | 223.26800 |
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| Flash Point | 216ºC |
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| Exact Mass | 223.12100 |
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| PSA | 58.56000 |
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| LogP | 1.86770 |
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| Vapour Pressure | 2.77E-08mmHg at 25°C |
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| Index of Refraction | 1.558 |
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| InChIKey | LIAWQASKBFCRNR-UHFFFAOYSA-N |
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| SMILES | CCOc1ccc(NC(=O)CC(C)O)cc1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- EU0900000
- CHEMICAL NAME :
- p-Butyrophenetidide, 3-hydroxy-
- CAS REGISTRY NUMBER :
- 1083-57-4
- BEILSTEIN REFERENCE NO. :
- 2725755
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C12-H17-N-O3
- MOLECULAR WEIGHT :
- 223.30
- WISWESSER LINE NOTATION :
- Q3VMR DO2
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 790 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 958 gm/kg/76W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 479 gm/kg/76W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 2 umol/plate
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 33,2877,1985
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Safety Information
| Symbol |
GHS07, GHS08 |
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| Signal Word | Danger |
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| Hazard Statements | H312-H332-H350 |
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| Precautionary Statements | P201-P280-P308 + P313 |
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| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
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| Hazard Codes | T |
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| Risk Phrases | 45-46-20/21/22 |
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| Safety Phrases | 53-22-36/37/39-45 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | EU0900000 |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles5
More Articles
| Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice. J. Natl. Cancer Inst. 79(5) , 1151-8, (1987) The carcinogenicity of bucetin [(3-hydroxy-p-butyrophenetidide) CAS: 1083-57-4], an antipyretic analgesic drug, was examined in 300 (C57BL/6 X C3H)F1 mice. Groups of 50 mice of each sex were treated w... | |
| Mechanism of metabolic activation of the analgetic bucetin to bacterial mutagens by hamster liver microsomes. Chem. Pharm. Bull. 33(7) , 2877-85, (1985)
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| [Biopharmaceutical studies of drugs. III. Serum concentration level of o-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine after simultaneous administration to rabbit (author's transl)]. Yakugaku Zasshi 101(6) , 556-66, (1981)
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Synonyms
| N-(4-ethoxyphenyl)-3-hydroxybutanamide |
| N-(3-Hydroxybutyryl)-p-phenetidine |
| 3-Hydroxy-p-butyrophenetidide (N-(4-Ethoxyphenyl)-3-hydroxybutanamide |
| MFCD00021906 |
| 3-Hydroxy-p-butyrophenetidine |
| 4'-Ethoxy-3-hydroxybutyranilide |
| Bucetin |
