Introduction：Basic information about CAS 32383-76-9|Medicarpin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Medicarpin |
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| CAS Number | 32383-76-9 | Molecular Weight | 270.280 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 418.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C16H14O4 | Melting Point | 127.5-128.5° |
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| MSDS | / | Flash Point | 207.1±28.7 °C |
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Names
| Name | (-)-medicarpin |
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| Synonym | More Synonyms |
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Medicarpin BiologicalActivity
| Description | Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of drugs[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | Medicarpin (90 µM; for 48 h) triggers apoptosis in sensitive as well as multidrug resistant P388 cells. P-glycoprotein-expressing P388/DOX cells does not show resistance to medicarpin (IC50≈90 µM for P388 and P388/DOX cells)[1]. |
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| References | [1]. Grégory Gatouillat, et al. Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells. medicine. 2015 Dec 1;22(13):1186-94. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 418.8±45.0 °C at 760 mmHg |
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| Melting Point | 127.5-128.5° |
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| Molecular Formula | C16H14O4 |
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| Molecular Weight | 270.280 |
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| Flash Point | 207.1±28.7 °C |
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| Exact Mass | 270.089203 |
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| PSA | 47.92000 |
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| LogP | 2.72 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.630 |
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| InChIKey | NSRJSISNDPOJOP-BBRMVZONSA-N |
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| SMILES | COc1ccc2c(c1)OC1c3ccc(O)cc3OCC21 |
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Safety Information
Synonyms
| l-3-Hydroxy-9-methoxypterocarpan |
| 6H-Benzofuro[3,2-c][1]benzopyran-3-ol, 6a,11a-dihydro-9-methoxy-, (6aR-cis)- |
| UNII-6TX086I6IG |
| (-)-3-Hydroxy-9-methoxypterocarpan |
| 3-hydroxy-9-methoxypterocarpan |
| Demethylhomopterocarpin |
| Medicarpin |
| 6H-Benzofuro[3,2-c][1]benzopyran-3-ol, 6a,11a-dihydro-9-methoxy-, (6aR,11aR)- |
| (6aR-cis)-6a,11a-Dihydro-9-methoxy-6H-benzofuro[3,2-c][1]benzopyran-3-ol |
| (6aR,11aR)-9-Methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol |
| Medicarpin, (-)- |
| demethylhomopterocarpan |
