Introduction：Basic information about CAS 88416-50-6|Clodronate disodium tetrahydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Clodronate disodium tetrahydrate |
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| CAS Number | 88416-50-6 | Molecular Weight | 360.917 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | CH12Cl2Na2O10P2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Disodium Clodronate Tetrahydrate |
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| Synonym | More Synonyms |
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Clodronate disodium tetrahydrate BiologicalActivity
| Description | Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
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| Target | vesicular ATP release[1] |
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| In Vitro | Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission [1]. Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence [1]. Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis[2]. |
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| In Vivo | Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1]. Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1]. Animal Model: C57BL/6 mice (22-30 g)[1] Dosage: 10 mg/kg Administration: Intravenous injection Result: Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain. |
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| References | [1]. Kato Y, et al. Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6297-E6305. [2]. Moriyama Y, et al. Clodronate: A Vesicular ATP Release Blocker. Trends Pharmacol Sci. 2018 Jan;39(1):13-23. |
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Chemical & Physical Properties
| Molecular Formula | CH12Cl2Na2O10P2 |
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| Molecular Weight | 360.917 |
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| Exact Mass | 359.892151 |
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| PSA | 177.26000 |
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| LogP | 1.04990 |
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| InChIKey | XWHPUCFOTRBMGS-UHFFFAOYSA-L |
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| SMILES | O.O.O.O.O=P([O-])(O)C(Cl)(Cl)P(=O)([O-])O.[Na+].[Na+] |
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Synonyms
| Sodium (dichloromethylene)bis[hydrogen (phosphonate)] hydrate (2:1:4) |
| Phosphonic acid, (dichloromethylene)bis-, sodium salt, hydrate (1:2:4) |
| Disodium clodronate tetrahydrate |
| clodronate disodium tetrahydrate |
| Clodronate Disodium |
