Introduction：Basic information about CAS 23360-92-1|vinleurosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | vinleurosine |
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| CAS Number | 23360-92-1 | Molecular Weight | 808.96 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C46H56N4O9 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | leurosine |
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| Synonym | More Synonyms |
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vinleurosine BiologicalActivity
| Description | Vinleurosine is an indole alkaloid with antineoplastic activity[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. W A Creasey, et al. Biochemical effects of the Vinca alkaloids. IV. Studies with vinleurosine. Biochem Pharmacol. 1969 Jan;18(1):227-32. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C46H56N4O9 |
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| Molecular Weight | 808.96 |
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| Exact Mass | 808.404724 |
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| PSA | 146.40000 |
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| LogP | 4.08 |
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| Index of Refraction | 1.678 |
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| InChIKey | LPGWZGMPDKDHEP-NVDFJPPOSA-N |
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| SMILES | CCC12CN3CCc4c([nH]c5ccccc45)C(C(=O)OC)(c4cc5c(cc4OC)N(C)C4C(O)(C(=O)OC)C(OC(C)=O)C6(CC)C=CCN7CCC54C76)CC(C3)C1O2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OH6370000
- CHEMICAL NAME :
- Leurosine
- CAS REGISTRY NUMBER :
- 23360-92-1
- BEILSTEIN REFERENCE NO. :
- 0079636
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C46-H56-N4-O9
- MOLECULAR WEIGHT :
- 809.06
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15200 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg/30D-I
- TOXIC EFFECTS :
- Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 mg/kg/15D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987
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Safety Information
| RIDADR | UN 1544 |
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| Packaging Group | II |
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| Hazard Class | 6.1(a) |
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Synonyms
| (2'β,4'α,5'α)-O',5'-Cyclovincaleukoblastine |
| 4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester |
| O,5'-Cyclovincaleukoblastine, (2'β,4'α,5'α)- |
| (2'β,3'β)-O',3'-Cyclovincaleukoblastine |
| (3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine |
| O,3'-Cyclovincaleukoblastine, (2'β,3'β)- |
| vinleurosine |
| amotin |
| 4'-Deoxy-3',4'-epoxyvincaleucoblastine,9CI |
| Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'a,4'a)- |
| Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'α,4'α)- |
