CAS 6035-45-6|Leucovorin Calcium Pentahydrate

Introduction：Basic information about CAS 6035-45-6|Leucovorin Calcium Pentahydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Leucovorin Calcium Pentahydrate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Leucovorin Calcium Pentahydrate
CAS Number	6035-45-6	Molecular Weight	601.58
Density	/	Boiling Point	/
Molecular Formula	C₂₀H₃₁CaN₇O₁₂	Melting Point	240-250ºC
MSDS	/	Flash Point	/

Names

Name	Calcium folinatc
Synonym	More Synonyms

Leucovorin Calcium Pentahydrate BiologicalActivity

Description	Folinic Acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.Target: Folate analogApproved: 2008Folinic acid (calcium salt pentahydrate) is the calcium salt form of folinic acid, which is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. Folinic acid in the body can be converted into any of the other active forms of folate.Treatment with folinic acid calcium salt pentahydrate (CF) could cause improved development in the heart and vessels in MTX-treated embryos, which proved that MTX induced the malformations by inhibiting DHFR. The transcript levels of genes such as hand2, mef2a, mef2c, and flk-1 were reduced in MTX-treated embryos. Compared with the MTX-treated group, the transcript levels of hand2, mef2a, mef2c, and flk-1 were increased in the MTX + dhfr-gfp mRNA-injected group and in the MTX + CF group [1]. Folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be re-dosed until the methotrexate level is less than 5 x 10-8 M [2].
Related Catalog	Signaling Pathways >>Cell Cycle/DNA Damage >>AntifolateResearch Areas >>Cancer
References	[1]. Sun, S., et al., Effects of methotrexate on the developments of heart and vessel in zebrafish. Acta Biochim Biophys Sin (Shanghai), 2009. 41(1): p. 86-96. [2]. www.cancercare.on.ca/pdfdrugs/leucovo.pdf

Description

Folinic Acid is a reduced folic acid, which is used in combination with other chemotherapy drugs.Target: Folate analogApproved: 2008Folinic acid (calcium salt pentahydrate) is the calcium salt form of folinic acid, which is one of the forms of folate found naturally in foods. Folate deficiency is believed to be the most common vitamin deficiency in the world due to food processing, food selection, and intestinal disorders. Folinic acid in the body can be converted into any of the other active forms of folate.Treatment with folinic acid calcium salt pentahydrate (CF) could cause improved development in the heart and vessels in MTX-treated embryos, which proved that MTX induced the malformations by inhibiting DHFR. The transcript levels of genes such as hand2, mef2a, mef2c, and flk-1 were reduced in MTX-treated embryos. Compared with the MTX-treated group, the transcript levels of hand2, mef2a, mef2c, and flk-1 were increased in the MTX + dhfr-gfp mRNA-injected group and in the MTX + CF group [1]. Folinic acid may also be useful in the treatment of acute methotrexate overdose. Different dosing protocols are used, but folinic acid should be re-dosed until the methotrexate level is less than 5 x 10-8 M [2].

Related Catalog

Signaling Pathways >>Cell Cycle/DNA Damage >>AntifolateResearch Areas >>Cancer

References

[1]. Sun, S., et al., Effects of methotrexate on the developments of heart and vessel in zebrafish. Acta Biochim Biophys Sin (Shanghai), 2009. 41(1): p. 86-96.

[2]. www.cancercare.on.ca/pdfdrugs/leucovo.pdf

Chemical & Physical Properties

Melting Point	240-250ºC
Molecular Formula	C₂₀H₃₁CaN₇O₁₂
Molecular Weight	601.58
PSA	427.76000
InChIKey	NPPBLUASYYNAIG-ZIGBGYJWSA-L
SMILES	Nc1nc2c(c(=O)[nH]1)N(C=O)C(CNc1ccc(C(=O)NC(CCC(=O)[O-])C(=O)[O-])cc1)CN2.O.O.O.O.O.[Ca+2]
Storage condition	-20℃

Safety Information

Hazard Codes	Xn: Harmful;
Risk Phrases	36/37/38-42/43
Safety Phrases	26-36
WGK Germany	3
HS Code	2942000000

Customs

HS Code	2942000000

Synonyms

Folaren

Foliben

5-formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt

FOLINIC ACID CALCIUM CELL CULTURE TESTED

Folinic acid calcium salt

Folidan

Leucovorin 30(R)

CALCIUM FOLINATE(FOLINIC ACID)(RG)

Calcium 2-amino-6-[(4-{[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl}phenyl)(methyl)amino]-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridine 2-amino-6-[{4-[(1-carboxy-3-carboxylatopropyl)carbamoyl]phenyl}(methyl)amino]-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridine (1:1:1)

(6S)-calcium folinate

Leucovorin Calcium

Leucovorin calcium pentahydrate

FOLINIC ACID(SEE CALCIUM FOLINATE)

Folinic acid (calcium salt pentahydrate)

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