Introduction：Basic information about CAS 3230-94-2|L-Ornithine L-aspartate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-Ornithine L-aspartate salt |
|---|
| CAS Number | 3230-94-2 | Molecular Weight | 265.264 |
|---|
| Density | / | Boiling Point | 308.7ºC at 760 mmHg |
|---|
| Molecular Formula | C9H19N3O6 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | 140.5ºC |
|---|
Names
| Name | (2S)-2-aminobutanedioic acid,(2S)-2,5-diaminopentanoic acid |
|---|
| Synonym | More Synonyms |
|---|
L-Ornithine L-aspartate salt BiologicalActivity
| Description | L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis[1]. |
|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
|---|
| References | [1]. Sikorska H, et al. [Physiological functions of L-ornithine and L-aspartate in the body and the efficacy of administration of L-ornithine-L-aspartate in conditions of relative deficiency]. Pol Merkur Lekarski. 2010 Jun;28(168):490-5. |
|---|
Chemical & Physical Properties
| Boiling Point | 308.7ºC at 760 mmHg |
|---|
| Molecular Formula | C9H19N3O6 |
|---|
| Molecular Weight | 265.264 |
|---|
| Flash Point | 140.5ºC |
|---|
| Exact Mass | 265.127380 |
|---|
| PSA | 189.96000 |
|---|
| LogP | 0.11110 |
|---|
| InChIKey | IXUZXIMQZIMPSQ-ZBRNBAAYSA-N |
|---|
| SMILES | NC(CC(=O)O)C(=O)O.NCCCC(N)C(=O)O |
|---|
| Storage condition | 2-8°C |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CI9463000
- CAS REGISTRY NUMBER :
- 3230-94-2
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C5-H12-N2-O2.C4-H7-N-O4
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1968 Volume(issue)/page/year: -,91,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1968 Volume(issue)/page/year: -,91,1968
|
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|
| Hazard Codes | Xi: Irritant; |
|---|
| Risk Phrases | R36/37/38 |
|---|
| Safety Phrases | S26-S37/39 |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 2 |
|---|
| RTECS | CI9463000 |
|---|
| HS Code | 2922499990 |
|---|
Customs
| HS Code | 2922499990 |
|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
|---|
Articles26
More Articles
| Modulation of neural activation following treatment of hepatic encephalopathy. Neurology 80(11) , 1041-7, (2013) To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy.As proof of principle, 22 pati... | |
| L-Ornithine-l-aspartate in the management of hepatic encephalopathy: a meta-analysis. J. Gastroenterol. Hepatol. 24(1) , 9-14, (2009) Hepatic encephalopathy continues to be a major clinical problem and the current decade has not witnessed major therapeutic breakthroughs in this area. L-ornithine-l-aspartate (LOLA) is not frequently ... | |
| A double-blind, randomized, placebo-controlled trial of intravenous L-ornithine-L-aspartate on postural control in patients with cirrhosis. Liver Int. 30(4) , 574-82, (2010) Hepatic encephalopathy (HE) is a complication of liver disease. Several treatments have been introduced but only L-ornithine-L-aspartate (LOLA) shows proven efficacy. This double-blind, randomized, pl... | |
Synonyms
| L-Ornithine L-Aspartate Salt |
| L-Ornithine L-Aspartate |
| L-Ornithine-L-Aspartate |
| L-Aspartic acid - L-ornithine (1:1) |
| EINECS 221-772-7 |
| L-OrnithineL-aspartatesalt |
| (S)-2,5-Diaminopentanoic acid L-aspartate salt |
| Hepa-Merz (TN) |
| L-Ornithin-L-aspartat |
| L-Aspartic acid, compd. with L-ornithine (1:1) |
| MFCD00058084 |
| (S)-2,5-Diaminopentanoic acid compound with (S)-2-aminosuccinic acid |
