Introduction：Basic information about CAS 89371-37-9|Imidapril, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Imidapril |
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| CAS Number | 89371-37-9 | Molecular Weight | 405.44500 |
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| Density | 1.266 g/cm3 | Boiling Point | 577ºC at 760 mmHg |
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| Molecular Formula | C20H27N3O6 | Melting Point | 195-197°C |
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| MSDS | / | Flash Point | 302.8ºC |
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Names
| Name | (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid |
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| Synonym | More Synonyms |
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Imidapril BiologicalActivity
| Description | Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)Research Areas >>Metabolic DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>MMP |
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| Target | MMP-9 |
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| References | [1]. Robinson DM, et al. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78. [2]. Yamamoto D, et al. Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9. J Mol Cell Cardiol. 2007 Dec;43(6):670-6. |
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Chemical & Physical Properties
| Density | 1.266 g/cm3 |
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| Boiling Point | 577ºC at 760 mmHg |
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| Melting Point | 195-197°C |
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| Molecular Formula | C20H27N3O6 |
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| Molecular Weight | 405.44500 |
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| Flash Point | 302.8ºC |
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| Exact Mass | 405.19000 |
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| PSA | 116.25000 |
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| LogP | 1.14290 |
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| InChIKey | KLZWOWYOHUKJIG-BPUTZDHNSA-N |
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| SMILES | CCOC(=O)C(CCc1ccccc1)NC(C)C(=O)N1C(=O)N(C)CC1C(=O)O |
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| Storage condition | -20°C Freezer |
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Safety Information
| Risk Phrases | R22:Harmful if swallowed. R34:Causes burns. |
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| Safety Phrases | S26-S36/37/39 |
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| RIDADR | 1759 |
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| Packaging Group | II |
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| Hazard Class | 8 |
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Synonyms
| imidapril |
| (4S)-3-<(2S)-2-<N-<(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl>amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic Acid |
| Hipertene (TN) |
| Imidapril [BAN:INN] |
| Imidaprilum |
| (S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid |
| Imidapril HCl |
| (4S)-1-methyl-3-{(2S)-2-[N-(1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylic acid |
| Imidapril (INN) |
| Imidaprilum [INN-Latin] |
| MFCD00870777 |
