CAS 81525-10-2|Nafamostat

Introduction：Basic information about CAS 81525-10-2|Nafamostat, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nafamostat BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Nafamostat
CAS Number	81525-10-2	Molecular Weight	347.371
Density	1.4±0.1 g/cm3	Boiling Point	637.2±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇N₅O₂	Melting Point	/
MSDS	/	Flash Point	339.1±34.3 °C

Names

Name	nafamostat mesylate
Synonym	More Synonyms

Nafamostat BiologicalActivity

Description	Nafamostat is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation; is also a possible complement inhibitor.Target: Serine ProteaseTranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents.A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>Cardiovascular Disease
References	[1]. Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600. [2]. Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.

Description

Nafamostat is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation; is also a possible complement inhibitor.Target: Serine ProteaseTranilast (FUT-175) is an antiallergic drug for bronchial asthma. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. It has also been investigated for use as an antiproliferative drug on drug-eluting stents.A 20-40 mg/h dose of FUT-175 prolonged coagulation time sufficiently in the instrumental blood of the extracorporeal circuit but not in the systemic blood. Its anticoagulant activity decreased immediately after hemodialysis. Therefore, we could manage all patients without any bleeding trouble during hemodialysis with FUT-175 as an anticoagulant. Although there were side effects of FUT-175, such as nausea, vomiting, itching and eruption, they were not serious, and FUT-175 could be administered without interruption. FUT-175 seems to be useful as an anticoagulant during hemodialysis for patients susceptible to bleeding.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseResearch Areas >>Cardiovascular Disease

References

[1]. Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600.

[2]. Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	637.2±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇N₅O₂
Molecular Weight	347.371
Flash Point	339.1±34.3 °C
Exact Mass	347.138214
PSA	138.07000
LogP	1.93
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.694
InChIKey	MQQNFDZXWVTQEH-UHFFFAOYSA-N
SMILES	N=C(N)c1ccc2cc(OC(=O)c3ccc(N=C(N)N)cc3)ccc2c1
Storage condition	2-8℃

Synonyms

6-Carbamimidoyl-2-naphthyl 4-carbamimidamidobenzoate

6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate

Nafamostat Dimethanesulfonate

NAFAMOSTAT MESILATE

Benzoic acid, 4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester

6-Amidino-2-naphthyl-4-guanidinobenzoate

Futhan

6-AMIDINO-2-NAPHTHYL-4-GUANIDINOENZOATE,MESYLATE

Nafamstat

Nafamostat

6-carbamimidoylnaphthalen2-yl 4-(diaminomethyleneamino) benzoate

FUT-175

6-Amidino-2-naphthyl 4-guanidinobenzoate

NafamostatMesilateBase

4-[(Aminoiminomethyl)amino]benzoic Acid 6-(Aminoiminomethyl)-2-naphthalenyl Ester

4-Guanidinobenzoic acid 6-amidino-2-naphtyl ester

Recommended......