CAS 56-86-0|L-glutamic acid

Introduction：Basic information about CAS 56-86-0|L-glutamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. L-glutamic acid BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles365
8. Synonyms

Common Name	L-glutamic acid
CAS Number	56-86-0	Molecular Weight	147.129
Density	1.4±0.1 g/cm3	Boiling Point	333.8±32.0 °C at 760 mmHg
Molecular Formula	C₅H₉NO₄	Melting Point	205 °C (dec.)(lit.)
MSDS	USA	Flash Point	155.7±25.1 °C

Names

Name	L-glutamic acid
Synonym	More Synonyms

L-glutamic acid BiologicalActivity

Description	(S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
Related Catalog	Natural Products >>OthersResearch Areas >>Neurological Disease
Target	Human Endogenous Metabolite DA
References	[1]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	333.8±32.0 °C at 760 mmHg
Melting Point	205 °C (dec.)(lit.)
Molecular Formula	C₅H₉NO₄
Molecular Weight	147.129
Flash Point	155.7±25.1 °C
Exact Mass	147.053162
PSA	100.62000
LogP	-1.43
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.522
Water Solubility	7.5 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ9700000

CHEMICAL NAME :: Glutamic acid, L-

CAS REGISTRY NUMBER :: 56-86-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C5-H9-N-O4

MOLECULAR WEIGHT :: 147.15

WISWESSER LINE NOTATION :: QVYZ2VQ -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Behavioral - headache

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 117 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >30 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80420 No. of Facilities: 446 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 10592 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80420 No. of Facilities: 915 (estimated) No. of Industries: 10 No. of Occupations: 27 No. of Employees: 11240 (estimated) No. of Female Employees: 5754 (estimated)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	LZ9700000
HS Code	2922421000

Customs

HS Code	2922421000
Summary	HS: 2922421000. (s)-2-aminopentanedioic acid. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:10.0%. general tariff:90.0%

Articles365

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.

J. Mol. Biol. 426(24) , 4049-60, (2014)

Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress respons...

EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.

J. Neurosci. 34(40) , 13472-85, (2014)

The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despit...

Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling

J. Steroid Biochem. Mol. Biol. 144 Pt B , 334-47, (2014)

• Age-dependent action of nonylphenol (NP) on mouse neuronal cells was demonstrated. • Estrogen receptor (ER) antagonists potentiated the NP-induced apoptosis and toxicity. • ER agonists inhibited the...

Synonyms

L-Glutamic acid

Glusate

H-L-GLU-OH

L-GLU

H-GLU-OH

GLU

L-Glutamicacid

GLUTACID

Aciglut

EINECS 200-293-7

MFCD00002634

glutamic

Glutaton

(S)-Glutamic acid

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