CAS 102783-53-9|2,3-DIPHOSPHO-D-GLYCERIC ACID PENTASODIUM SALT
| Common Name | 2,3-DIPHOSPHO-D-GLYCERIC ACID PENTASODIUM SALT | ||
|---|---|---|---|
| CAS Number | 102783-53-9 | Molecular Weight | 375.946 |
| Density | / | Boiling Point | / |
| Molecular Formula | C3H3Na5O10P2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 2,3-Diphospho-D-glyceric acid pentasodium salt |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | 2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| References | [1]. Kharaghani D, Kohno S, Minamizaki T, et al. 2, 3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells[J]. Colloid and Interface Science Communications, 2022, 50: 100668. |
Chemical & Physical Properties
| Molecular Formula | C3H3Na5O10P2 |
|---|---|
| Molecular Weight | 375.946 |
| Exact Mass | 375.868988 |
| PSA | 204.59000 |
| InChIKey | KPRMRMXBVAUXKZ-WXQRJNCRSA-I |
| SMILES | O=C([O-])C(COP(=O)([O-])[O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+] |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles20
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| Development of a bifunctional filter for prion protein and leukoreduction of red blood cell components. Transfusion 55(2) , 330-6, (2015) Leukofiltration of blood components is currently implemented worldwide as a precautionary measure against white blood cell-associated adverse effects and the potential transmission of variant Creutzfe... | |
| Red blood cell in vitro quality and function is maintained after S-303 pathogen inactivation treatment. Transfusion 54(7) , 1798-807, (2014) Over the past decade there has been a growth in the development of pathogen reduction technologies to protect the blood supply from emerging pathogens. This development has proven to be difficult for ... |
Synonyms
| Pentasodium (2R)-2,3-bis(phosphonatooxy)propanoate |
| Propanoic acid, 2,3-bis(phosphonooxy)-, sodium salt, (2R)- (1:5) |
| 2,3-diphospho-d-glyceric acid pentasodium salt |
