CAS 56-84-8|L-Aspartic acid
| Common Name | L-Aspartic acid | ||
|---|---|---|---|
| CAS Number | 56-84-8 | Molecular Weight | 133.103 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 264.1±30.0 °C at 760 mmHg |
| Molecular Formula | C4H7NO4 | Melting Point | >300 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 113.5±24.6 °C |
Names
| Name | L-aspartic acid |
|---|---|
| Synonym | More Synonyms |
L-Aspartic acid BiologicalActivity
| Description | L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly. |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Cardiovascular Disease |
| Target | Human Endogenous Metabolite |
| In Vivo | L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2]. |
| References | [1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 264.1±30.0 °C at 760 mmHg |
| Melting Point | >300 °C (dec.)(lit.) |
| Molecular Formula | C4H7NO4 |
| Molecular Weight | 133.103 |
| Flash Point | 113.5±24.6 °C |
| Exact Mass | 133.037506 |
| PSA | 100.62000 |
| LogP | -0.67 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.531 |
| InChIKey | CKLJMWTZIZZHCS-REOHCLBHSA-N |
| SMILES | NC(CC(=O)O)C(=O)O |
| Water Solubility | 5 g/L (25 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25079 mg/kg/7D-C
- TOXIC EFFECTS :
- Liver - other changes Biochemical - Metabolism (Intermediary) - lipids including transport
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81861 No. of Facilities: 803 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 5939 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81861 No. of Facilities: 634 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9033 (estimated) No. of Female Employees: 6545 (estimated)
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81861 No. of Facilities: 803 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 5939 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81861 No. of Facilities: 634 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 9033 (estimated) No. of Female Employees: 6545 (estimated)
Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant;Xn: Harmful; |
| Risk Phrases | R36 |
| Safety Phrases | S26-S24/25-S22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | CI9098500 |
| HS Code | 29224995 |
Customs
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| asparagic acid |
| 1-amino-1,2-carboxyethane |
| δ-aspartic acid |
| d-Asp |
| QVYZ1VQ &&D or R Form |
| (-)-Aspartic acid |
| (2R)-2-Aminosuccinic acid |
| MFCD00002616 |
| (2R)-2-aminobutanedioic acid |
| hydrogen D-aspartate |
| L-Asparticacid |
| (R)-(−)-Aminosuccinic acid |
| D-(-)-Aspartic acid |
| Acide (2R)-2-aminosuccinique |
| L-Aspartic acid |
| aspartic acid D-form |
| Aspartic acid, D- |
| D-Aspartic acid |
| H-D-Asp-OH |
| EINECS 200-291-6 |
| H-Asp-OH |
