CAS 89796-99-6|Aceclofenac
| Common Name | Aceclofenac | ||
|---|---|---|---|
| CAS Number | 89796-99-6 | Molecular Weight | 354.185 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 486.0±45.0 °C at 760 mmHg |
| Molecular Formula | C16H13Cl2NO4 | Melting Point | 149-153°C |
| MSDS | ChineseUSA | Flash Point | 247.8±28.7 °C |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | aceclofenac |
|---|---|
| Synonym | More Synonyms |
Aceclofenac BiologicalActivity
| Description | Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.Target: COXAceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) which cause pain, swelling and inflammation. Aceclofenac is the glycolic acid ester of diclofenac [1]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/Immunology |
| Target | COX-2:3 μM (IC50) COX-1:7.3 μM (IC50) |
| References | [1]. Dannhardt G, et al. In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells (BAECs). Inflamm Res. 2001 May;50(5):262-9. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 486.0±45.0 °C at 760 mmHg |
| Melting Point | 149-153°C |
| Molecular Formula | C16H13Cl2NO4 |
| Molecular Weight | 354.185 |
| Flash Point | 247.8±28.7 °C |
| Exact Mass | 353.022156 |
| PSA | 75.63000 |
| LogP | 4.16 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.639 |
| InChIKey | MNIPYSSQXLZQLJ-UHFFFAOYSA-N |
| SMILES | O=C(O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl |
| Storage condition | -20°C Freezer |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1265,1991
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319-H410 |
| Precautionary Statements | P273-P301 + P310-P305 + P351 + P338-P501 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36 |
| RIDADR | 2811.0 |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
| HS Code | 2922509090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles37
More Articles| Development and implication of methodology for aceclofenac in pure and pharmaceutical formulations by microwave assisted spectrophotometry. Pak. J. Pharm. Sci. 26(1) , 169-73, (2013) A simple, fast and cost effective method for determination of aceclofenac in pure and tablet formulations has been developed and validated. The method is based on formation of stable blue coloured com... | |
| Electrospun zein/eudragit nanofibers based dual drug delivery system for the simultaneous delivery of aceclofenac and pantoprazole. Int. J. Pharm. 438(1-2) , 117-22, (2012) Electrospun composite zein/eudragit nanofibers were developed with an aim to deliver two different classes of drugs simultaneously that would restrict/compensate the adverse effects of non-steroidal a... | |
| Absolute bioavailability and metabolism of aceclofenac in rats. Arch. Pharm. Res. 38(1) , 68-72, (2015) Aceclofenac is one of the most popular analgesic and anti-inflammatory drugs used for the relief of pain, rheumatoid arthritis, and osteoarthritis. To date, no intravenous preparation of aceclofenac h... |
Synonyms
| Acelofenac |
| Aceclofenac |
| EINECS 205-783-4 |
| Aceclofar |
| Preservex |
| MFCD00864296 |
| Falcol |
| (2-{2-[(2,6-Dichlorophenyl)amino]phenyl}acetoxy)acetic acid |
| Tresquim |
| Biofenac |
| Zerodol |
| Airtal |
| PR-82/3 |
| Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester |
| Gerbin |
