CAS 849061-97-8|Quercetin (hydrate)
| Common Name | Quercetin (hydrate) | ||
|---|---|---|---|
| CAS Number | 849061-97-8 | Molecular Weight | 320.251 |
| Density | / | Boiling Point | 714.6ºC at 760 mmHg |
| Molecular Formula | C15H10O7.x H2O | Melting Point | >300ºC |
| MSDS | ChineseUSA | Flash Point | 386ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | Quercetin hydrate |
|---|---|
| Synonym | More Synonyms |
Quercetin (hydrate) BiologicalActivity
| Description | Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3KSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>Mitophagy |
| Target | IC50: 2.4±0.6 μM (PI3K γ), 3.0±0.0 μM (PI3K δ), 5.4±0.3 μM (PI3K β)[1] |
| References | [1]. Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80. [2]. Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81. [3]. Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277. [4]. Tao Liu, et al. Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. Life Sci. 2020 Jul 20;118116. |
Chemical & Physical Properties
| Boiling Point | 714.6ºC at 760 mmHg |
|---|---|
| Melting Point | >300ºC |
| Molecular Formula | C15H10O7.x H2O |
| Molecular Weight | 320.251 |
| Flash Point | 386ºC |
| Exact Mass | 320.053223 |
| PSA | 140.59000 |
| LogP | 1.92370 |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| RIDADR | 2811.0 |
| RTECS | LK8950000 |
| Hazard Class | 6.1 |
| HS Code | 2932999099 |
Customs
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles202
More Articles| Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis. J. Biochem. Mol. Toxicol. 29(3) , 99-108, (2015) We aimed to explore the antiadipogenic and adipolysis effect of hesperetin in human mesenchymal stem cells (hMSCs)-induced adipogenesis. IC50 value of hesperetin was higher for hMSCs such as 149.2 ± 1... | |
| Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells. Neurochem. Int. 80 , 60-71, (2015) Gliomas are the most common and malignant primary brain tumours and are associated with a poor prognosis despite the availability of multiple therapeutic options. Quercetin, a traditional Chinese medi... | |
| The identification of a novel SIRT6 modulator from Trigonella foenum-graecum using ligand fishing with protein coated magnetic beads. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 105-11, (2014) SIRT6 is a histone deacetylase that has been proposed as a potential therapeutic target for metabolic disorders and the prevention of age-associated diseases. Thus the identification of compounds that... |
Synonyms
| 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one hydrate (1:1) |
| 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate (1:1) |
| 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one hydrate |
