CAS 50865-01-5|Disodium protoporphyrin IX
Introduction：Basic information about CAS 50865-01-5|Disodium protoporphyrin IX, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Disodium protoporphyrin IX | ||
|---|---|---|---|
| CAS Number | 50865-01-5 | Molecular Weight | 606.622 |
| Density | / | Boiling Point | 1128.9ºC at 760 mmHg |
| Molecular Formula | C34H32N4Na2O4 | Melting Point | / |
| MSDS | USA | Flash Point | 636.6ºC |
Names
| Name | Zinc Ionophore II |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Boiling Point | 1128.9ºC at 760 mmHg |
|---|---|
| Molecular Formula | C34H32N4Na2O4 |
| Molecular Weight | 606.622 |
| Flash Point | 636.6ºC |
| Exact Mass | 606.221924 |
| PSA | 136.56000 |
| LogP | 1.37120 |
| InChIKey | GPRXGEKBQVXWAQ-UHFFFAOYSA-L |
| SMILES | C=Cc1c(C)c2cc3[nH]c(cc4nc(cc5nc(cc1[nH]2)C(C)=C5CCC(=O)[O-])C(CCC(=O)[O-])=C4C)c(C)c3C=C.[Na+].[Na+] |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1192,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1029 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1147 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 484 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,729,1982
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | TS5450000 |
Articles50
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| Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat. Med. 19(4) , 418-20, (2013) Co-therapy with rifampicin (RIF) and isoniazid (INH) used to treat tuberculosis in humans frequently causes liver injury. Here, using a pregnane X receptor (PXR)-humanized mouse model, we found that c... | |
| Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity. Mol. Pharmacol. 84(6) , 824-33, (2013) Salicylic acid is a classic nonsteroidal anti-inflammatory drug. Although salicylic acid also induces mitochondrial injury, the mechanism of its antimitochondrial activity is not well understood. In t... |
Synonyms
| EINECS 256-815-9 |
| 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-, sodium salt (1:2) |
| Disodium 3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphyrindiyl)dipropanoate |
| MFCD00151108 |
| Disodium protoporphyrin IX |
| Disodium 3,3'-(3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-diyl)dipropanoate |
| 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic Acid Disodium Salt |
| Protoporphyrin DisodiuM Salt |
