CAS 17070-45-0|1,3-Propanediamine,N1-(2-chloroethyl)-N3-(6-chloro-2-methoxy-9-acridinyl)-, hydrochlo
Introduction：Basic information about CAS 17070-45-0|1,3-Propanediamine,N1-(2-chloroethyl)-N3-(6-chloro-2-methoxy-9-acridinyl)-, hydrochlo, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,3-Propanediamine,N1-(2-chloroethyl)-N3-(6-chloro-2-methoxy-9-acridinyl)-, hydrochloride (1:2) | ||
|---|---|---|---|
| CAS Number | 17070-45-0 | Molecular Weight | 451.21700 |
| Density | / | Boiling Point | / |
| Molecular Formula | C19H23Cl4N3O | Melting Point | 261-262ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Melting Point | 261-262ºC |
|---|---|
| Molecular Formula | C19H23Cl4N3O |
| Molecular Weight | 451.21700 |
| Exact Mass | 449.06000 |
| PSA | 46.18000 |
| LogP | 6.74830 |
| InChIKey | LMEMIKWTNPWYMI-UHFFFAOYSA-N |
| SMILES | COc1ccc2nc3cc(Cl)ccc3c(NCCCNCCCl)c2c1.Cl.Cl |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD20 - Lethal Dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Amphibian - frog Embryo
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 94,187,1978
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Amphibian - frog Embryo
- DOSE/DURATION :
- 1 umol/L
- REFERENCE :
- JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 94,187,1978
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H310-H330-H350 |
| Precautionary Statements | P201-P260-P264-P280-P284-P302 + P350 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | 45-46-26/27/28 |
| Safety Phrases | 53-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 1 |
| RTECS | AR7678000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
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| Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin. Biophys. Chem. 135(1-3) , 69-75, (2008) We have investigated the ability of chlorophyllin (CHL) to interact with acridine mutagen ICR-191 (2-methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino)acridine) and also its ability to decrease bi... |
Synonyms
| AMES MUTAGEN 191 |
| ICR-191ACRIDINE |
| icr-191 |
| MFCD00013320 |
| ACRIDINE MUTAGEN ICR 191 |
| icr-191a |
| ICR 191 ACRIDINE MUTAGEN DIHYDROCHLORIDE |
| ICR-191DIHYDROCHLORIDE |
| 6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride |
| EINECS 241-129-4 |
| ICR 191 ACRIDINE MUTAGEN |
| ACRIDINEICR191 |
| icrdihydrochloride |
