CAS 99519-84-3|L-651,582
| Common Name | L-651,582 | ||
|---|---|---|---|
| CAS Number | 99519-84-3 | Molecular Weight | 424.67 |
| Density | 1.65g/cm3 | Boiling Point | 685.5ºC at 760 mmHg |
| Molecular Formula | C17H12Cl3N5O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 368.3ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide |
|---|---|
| Synonym | More Synonyms |
L-651,582 BiologicalActivity
| Description | Carboxyamidotriazole (L 651582; CAI) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>CancerResearch Areas >>Inflammation/Immunology |
| Target | Calcium channel[1] |
| References | [1]. Chen C, et al. Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis. J Pharmacol Exp Ther. 2017 Aug;362(2):219-229. [2]. Hussain MM, et al. J Clin Oncol. 2003 Dec 1;21(23):4356-63. |
Chemical & Physical Properties
| Density | 1.65g/cm3 |
|---|---|
| Boiling Point | 685.5ºC at 760 mmHg |
| Molecular Formula | C17H12Cl3N5O2 |
| Molecular Weight | 424.67 |
| Flash Point | 368.3ºC |
| Exact Mass | 423.00600 |
| PSA | 116.89000 |
| LogP | 4.48020 |
| Index of Refraction | 1.73 |
| InChIKey | WNRZHQBJSXRYJK-UHFFFAOYSA-N |
| SMILES | NC(=O)c1nnn(Cc2cc(Cl)c(C(=O)c3ccc(Cl)cc3)c(Cl)c2)c1N |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Hazard Codes | T+ |
| RIDADR | UN 2811 6.1 / PGIII |
Articles37
More Articles| Comparison of the applicability of mass spectrometer ion sources using a polarity- molecular weight scattergram with a 600 sample in-house chemical library. Eur. J. Mass Spectrom. (Chichester, Eng.) 21 , 91-6, (2015) To provide a practical guideline for the selection of a mass spectrometer ion source, we compared the applicability of three types of ion source: direct analysis in real time (DART), electrospray ioni... | |
| Differentially expressed and activated proteins associated with non small cell lung cancer tissues. Respir. Res. 16 , 74, (2015) Lung cancer is a leading cause of mortality. The most common cancer subtype, non small cell lung cancer (NSCLC), accounts for 85-90% all cases and is mainly caused by environmental and genetic factors... | |
| Intergenerational cultural conflict, mental health, and educational outcomes among Asian and Latino/a Americans: Qualitative and meta-analytic review. Psychol. Bull. 141(2) , 404-46, (2015) Among immigrant Asian and Latino groups, the contrast between collectivism in traditional heritage and individualism in the mainstream American cultures presents unique challenges for their family rel... |
Synonyms
| 4-CAI |
| CAI |
| Carboxyamido-triazole |
| Carboxyamidotriazole |
