CAS 99566-27-5|Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2
| Common Name | Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2 | ||
|---|---|---|---|
| CAS Number | 99566-27-5 | Molecular Weight | 1081.27 |
| Density | 1.38 g/cm3 | Boiling Point | / |
| Molecular Formula | C54H76N14O10 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Neuropeptide FF |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| References | [1]. Mankus JV, et al. Nonpeptide ligands of neuropeptide FF: current status and structural insights. Future Med Chem. 2012 Jun;4(9):1085-92. [2]. Jhamandas JH, et al. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8. |
Chemical & Physical Properties
| Density | 1.38 g/cm3 |
|---|---|
| Molecular Formula | C54H76N14O10 |
| Molecular Weight | 1081.27 |
| Exact Mass | 1080.59000 |
| PSA | 412.10000 |
| LogP | 4.54270 |
| Index of Refraction | 1.656 |
| InChIKey | HWYCFZUSOBOBIN-AQJXLSMYSA-N |
| SMILES | CC(C)CC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O |
| Storage condition | −20°C |
| Water Solubility | Soluble to 0.50 mg/ml in water. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles28
More Articles| The anti-inflammatory potential of neuropeptide FF in vitro and in vivo. Peptides 47 , 124-32, (2013) Neuropeptide FF (NPFF) has many functions in regulating various biological processes. However, little attention has been focused on the anti-inflammatory effect of this peptide. In the present study, ... | |
| Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test. Peptides 30(9) , 1683-8, (2009) GPR103 is one of the orphan G protein-coupled receptors. Recently, an endogenous ligand for GPR103, 26RFa, was identified. Many 26RFa binding sites have been observed in various nuclei of the brain in... | |
| Pressor and tachycardic responses to intrathecal administration of neuropeptide FF in anesthetized rats. Peptides 31(4) , 683-8, (2010) Neuropeptide FF (NPFF) belongs to a neuropeptide family including two precursors (pro-NPFF(A) and pro-NPFF(B)) and two receptors (NPFF(1) and NPFF(2)). NPFF and NPFF receptor mRNAs have been reported ... |
Synonyms
| H-PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 |
| ninamide |
| NPFF |
| PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE |
| F-8-F-NH2 |
| PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 |
| MFCD00076704 |
| F-8-F-NH2,NPFF,F-8-F-aMide |
| TC Mps1 12 |
| Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2 |
