CAS 29876-14-0|Nicotredole

Introduction：Basic information about CAS 29876-14-0|Nicotredole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nicotredole BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Nicotredole
CAS Number	29876-14-0	Molecular Weight	265.310
Density	1.2±0.1 g/cm3	Boiling Point	588.4±35.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₅N₃O	Melting Point	/
MSDS	/	Flash Point	309.7±25.9 °C

Names

Name	N-[2-(1H-indol-3-yl)ethyl]pyridine-3-carboxamide
Synonym	More Synonyms

Nicotredole BiologicalActivity

Description	Nicotredole (Tryptamide) is an orally active anti-inflammatory and analgesic agent. Nicotredole exhibits evident antiinflammatory effects of potency comparable with Phenylbutazone. Nicotredole has only weak ulcerogenic activity[1][2][3].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In Vitro	Nicotredole inhibits prostaglandin synthetase activity in vitro[1].
In Vivo	Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema[1]. Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice[1]. Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively[1]. Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively[1]. Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t1/2=4.92-17.5 min) and elimination (t1/2=55.72-74.52 min), can reach Cmax (11-13 μg/cm3) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm3)[2].
References	[1]. Herman ZS, et, al. Basic pharmacological properties of a novel antiinflammatory drug tryptamide. Pol J Pharmacol Pharm. Nov-Dec 1987;39(6):729-36. [2]. Szumiło H. Pharmacokinetics of tryptamide following oral and intraperitoneal administration in rats. Acta Pol Pharm. 1990;47(1-2):19-22. [3]. Kulig D, et, al. A comparison of anti-inflammatory, analgesic and ulcerogenic action of tryptamide, ibuprofen and piroxicam. Pol J Pharmacol Pharm. Nov-Dec 1987;39(6):769-72.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	588.4±35.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₅N₃O
Molecular Weight	265.310
Flash Point	309.7±25.9 °C
Exact Mass	265.121521
PSA	57.78000
LogP	1.94
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.669
InChIKey	ZDAZUJBASMCUAK-UHFFFAOYSA-N
SMILES	O=C(NCCc1c[nH]c2ccccc12)c1cccnc1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS4476800

CHEMICAL NAME :: Nicotinamide, N-(2-indol-3-ylethyl)-

CAS REGISTRY NUMBER :: 29876-14-0

BEILSTEIN REFERENCE NO. :: 0242441

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H15-N3-O

MOLECULAR WEIGHT :: 265.34

WISWESSER LINE NOTATION :: T56 BMJ D2MV- CT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA. Volume(issue)/page/year: 22,313,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 90 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,779,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 39,779,1987

Safety Information

Hazard Codes	Xi

Synonyms

nicotredole

3-Pyridinecarboxamide, N-[2-(1H-indol-3-yl)ethyl]-

Tryptamide

N-Nicotinoyltryptamide

N-[2-(1H-Indol-3-yl)ethyl]nicotinamide

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