Introduction：Basic information about CAS 66264-77-5|Sulfinalol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sulfinalol |
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| CAS Number | 66264-77-5 | Molecular Weight | 377.50 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H27NO4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-[1-hydroxy-2-[4-(4-methoxyphenyl)butan-2-ylamino]ethyl]-2-methylsulfinylphenol |
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| Synonym | More Synonyms |
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Sulfinalol BiologicalActivity
| Description | Sulfinalol is an orally active β-adrenoceptor antagonist with direct vasodilator activity[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | β-adrenoceptor |
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| In Vivo | Sulfinalol shows direct vasodilator activity and antihypertensive activity[1]. Animal Model: Mongrel dogs weighing 8.7-21.2 kg were anesthetized with pentobarbital (30-35 mg/kg, i.v., followed by a continuous infusion of 4 mg/kg/h)[1] Dosage: 0-100 µg Administration: Intraarterial injection Result: Increased blood flow in the sympathetically denervated hindlimb of anesthetized dogs. Animal Model: Male spontaneously hypertensive rats (SHR)[1] Dosage: 2.5 mg/kg Administration: Oral administration Result: Reduced pressure of conscious spontaneously hypertensive rats. |
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| References | [1]. E J Sybertz, et al. Studies on the mechanism of the acute antihypertensive and vasodilator actions of several beta-adrenoceptor antagonists. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):749-58. |
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Chemical & Physical Properties
| Molecular Formula | C20H27NO4S |
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| Molecular Weight | 377.50 |
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| Exact Mass | 377.16600 |
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| PSA | 98.00000 |
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| LogP | 4.03910 |
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| InChIKey | PAQZZCOZHPGCFW-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CCC(C)NCC(O)c2ccc(O)c(S(C)=O)c2)cc1 |
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Synonyms
