Introduction：Basic information about CAS 2922-74-9|2'-Deoxyadenosine-5'-monophosphate disodium salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2'-Deoxyadenosine-5'-monophosphate disodium salt |
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| CAS Number | 2922-74-9 | Molecular Weight | 375.185 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C10H12N5Na2O6P | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2'-Deoxyadenosine-5'-monophosphate disodium salt |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | 2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage[1]. |
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| Related Catalog | Research Areas >>Metabolic Disease |
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| In Vitro | 2′-Deoxyadenosine 5′-monophosphate (dAMP) is incorporated into Caco-2 cells in a time-dependent manner. The uptake of 2′-Deoxyadenosine 5′-monophosphate is increased with a drop in pH, suggesting that 2′-Deoxyadenosine 5′-monophosphate transport activity might be linked to the protons. 2′-Deoxyadenosine 5′-monophosphate uptake by Caco-2 cells is pH- and Na+-dependent[1]. |
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| References | [1]. Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14(10):e0223892. [2]. V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27(2):496-502. |
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Chemical & Physical Properties
| Molecular Formula | C10H12N5Na2O6P |
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| Molecular Weight | 375.185 |
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| Exact Mass | 375.032074 |
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| PSA | 181.31000 |
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| LogP | 0.62380 |
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| InChIKey | AYFGMFAEGVXUKY-VWZUFWLJSA-N |
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| SMILES | Nc1ncnc2c1ncn2C1CC(O)C(COP(=O)(O)O)O1.[Na] |
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| Storage condition | −20°C |
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| Water Solubility | H2O: 50 mg/mL, clear, colorless |
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Safety Information
| Hazard Codes | Xi,Xn |
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| Risk Phrases | 36/37/38-20/21/22 |
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| Safety Phrases | S22-S26-S36-S24/25-S37/39 |
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| WGK Germany | 3 |
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Synonyms
| MFCD00065990 |
| disodium 2'-deoxyadenosine 5'-monophosphate |
| 5'-Adenylic acid, 2'-deoxy-, sodium salt (1:2) |
| Disodium 2'-deoxy-5'-O-phosphonatoadenosine |
| EINECS 220-873-3 |
