CAS 1078-61-1|3,4-Dihydroxyhydrocinnamic acid
| Common Name | 3,4-Dihydroxyhydrocinnamic acid | ||
|---|---|---|---|
| CAS Number | 1078-61-1 | Molecular Weight | 182.173 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 417.5±30.0 °C at 760 mmHg |
| Molecular Formula | C9H10O4 | Melting Point | 136-139 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 220.4±21.1 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3-(3,4-dihydroxyphenyl)propanoic acid |
|---|---|
| Synonym | More Synonyms |
3,4-Dihydroxyhydrocinnamic acid BiologicalActivity
| Description | Dihydrocaffeic acid is a phenolic acid found in Gynura bicolor, reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Antioxidant potential and anti-inflammatory activity[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
| Target | p38 MAPK |
| References | [1]. Oliveira MM, et al. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxid Med Cell Longev. 2019 Jan 17;2019:2419096. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 417.5±30.0 °C at 760 mmHg |
| Melting Point | 136-139 °C(lit.) |
| Molecular Formula | C9H10O4 |
| Molecular Weight | 182.173 |
| Flash Point | 220.4±21.1 °C |
| Exact Mass | 182.057907 |
| PSA | 77.76000 |
| LogP | 0.50 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.620 |
| InChIKey | DZAUWHJDUNRCTF-UHFFFAOYSA-N |
| SMILES | O=C(O)CCc1ccc(O)c(O)c1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 150 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,523,1988
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 150 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,523,1988
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | MW5143500 |
Articles54
More Articles| A metabolite profiling approach to identify biomarkers of flavonoid intake in humans. J. Nucl. Med. 139 , 2309-14, (2009) Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio... | |
| Poly(N-vinylimidazole/ethylene glycol dimethacrylate) for the purification and isolation of phenolic acids. Anal. Chim. Acta 885 , 199-206, (2015) In this study we report the novel polymeric resin poly(N-vinyl imidazole/ethylene glycol dimethacrylate) for the purification and isolation of phenolic acids. The monomer to crosslinker ratio and the ... | |
| Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies. Bioorg. Med. Chem. 17 , 5219-28, (2009) In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop ... |
Synonyms
| Dihydrocaffeate |
| 3,4-dihydroxy-hydrocinnamicaci |
| Hydrocaffeate |
| hydrocaffeic acid |
| 3-propionic acid |
| 3,4-Dihydroxy-benzenepropanoic acid |
| 3,4-Dihydroxydihydrocinnamic acid |
| 3-(3,4-DIHYDROXYPHENYL)PROPIONIC ACID |
| 3,4-Dihydroxybenzenepropionate |
| 3,4-Dihydroxybenzenepropionic acid |
| dihydrocaffeic acid |
| 3,4-dihydroxyhydrocinnamic acid |
| 3-(3,4-Dihydroxyphenyl)propanoic acid |
| 3-(3,4-Dihydroxyphenyl)propionate |
| Benzenepropanoic acid, 3,4-dihydroxy- |
| 3,4-DIHYDROCAFFEIC ACID |
| 3,4-Dihydroxyhydrocinnamate |
| phloretic acid |
| EINECS 214-083-8 |
| 3-(3,4-Dihydroxyphenyl)propionic acid,Hydrocaffeic acid |
| Dihydrocafeate |
| MFCD00002776 |
