CAS 487-36-5|Pinoresinol
| Common Name | Pinoresinol | ||
|---|---|---|---|
| CAS Number | 487-36-5 | Molecular Weight | 358.385 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 556.5±50.0 °C at 760 mmHg |
| Molecular Formula | C20H22O6 | Melting Point | 121 °C |
| MSDS | USA | Flash Point | 290.4±30.1 °C |
Names
| Name | (+)-pinoresinol |
|---|---|
| Synonym | More Synonyms |
Pinoresinol BiologicalActivity
| Description | Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
| In Vitro | Pinoresinol facilitated death-inducing signaling complex formation to trigger a caspase-8-dependent apoptotic cascade activation in TRAIL-resistant glioblastoma cells[2]. |
| References | [1]. Schroeder FC, et al. Pinoresinol: A lignol of plant origin serving for defense in a caterpillar. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15497-501. [2]. Lee SR, et al. Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis. Sci Rep. 2019 Sep 18;9(1):13505. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 556.5±50.0 °C at 760 mmHg |
| Melting Point | 121 °C |
| Molecular Formula | C20H22O6 |
| Molecular Weight | 358.385 |
| Flash Point | 290.4±30.1 °C |
| Exact Mass | 358.141632 |
| PSA | 77.38000 |
| LogP | 1.54 |
| Appearance of Characters | white to tan |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.598 |
| InChIKey | HGXBRUKMWQGOIE-AFHBHXEDSA-N |
| SMILES | COc1cc(C2OCC3C(c4ccc(O)c(OC)c4)OCC23)ccc1O |
| Storage condition | ?20°C |
| Water Solubility | DMSO: ≥6mg/mL |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles26
More Articles| Characterisation and phenolic profiles of two rare olive oils from southern Tunisia: Dhokar and Gemri-Dhokar cultivars. J. Sci. Food Agric. 93(3) , 527-34, (2013) The aim of this work was to study the chemical characteristics of two Tunisian cultivars, namely Dhokar and Gemri-Dhokar, to analyse the fatty acids, sterols, triacylglycerols, triterpenic alcohols, a... | |
| [Study on the chemical constituents of the roots of Dendropanax chevalieri]. Zhong Yao Cai 35(1) , 62-4, (2012) To study the chemical constituents of the roots of Dendropanax chevalieri.The constituents were isolated by column chromatography with silica gel, Sephadex LH-20 gel and RP-18. Their structures were e... | |
| [Chemical constituents of the roots of Vaccinium bracteatum]. Zhong Yao Cai 35(6) , 917-9, (2012) To study the chemical constituents of the roots of Vaccinium bracteatum.The constituents were separated and purified with chromatographic methods (including silica gel, Sephadex LH-20 and RP-18 column... |
Synonyms
| (+)-PINORESINOL |
| 4,4'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2-methoxyphenol) |
| Phenol, 4,4'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxy- |
| Pinoresinol |
