Introduction：Basic information about CAS 29462-18-8|Bentazepam, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bentazepam |
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| CAS Number | 29462-18-8 | Molecular Weight | 296.38700 |
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| Density | 1.38g/cm3 | Boiling Point | 532.6ºC at 760 mmHg |
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| Molecular Formula | C17H16N2OS | Melting Point | / |
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| MSDS | / | Flash Point | 275.9ºC |
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Names
| Name | 5-phenyl-3,4,6,7,8,9-hexahydro-[1]benzothiolo[2,3-e][1,4]diazepin-2-one |
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| Synonym | More Synonyms |
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Bentazepam BiologicalActivity
| Description | Bentazepam (Thiadipone) is a compound with short-action anxiolytic effect. Bentazepam shows anticonvulsant and sedative properties. Bentazepam can be used for the research of depressive disorder and anxiety[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vivo | Bentazepam increases the anticonvulsive activity of clonazepam[1]. |
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Chemical & Physical Properties
| Density | 1.38g/cm3 |
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| Boiling Point | 532.6ºC at 760 mmHg |
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| Molecular Formula | C17H16N2OS |
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| Molecular Weight | 296.38700 |
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| Flash Point | 275.9ºC |
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| Exact Mass | 296.09800 |
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| PSA | 69.70000 |
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| LogP | 2.99000 |
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| Vapour Pressure | 2E-11mmHg at 25°C |
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| Index of Refraction | 1.733 |
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| InChIKey | AIZFEOPQVZBNGH-UHFFFAOYSA-N |
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| SMILES | O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DL8230000
- CHEMICAL NAME :
- 2H-(1)Benzothieno(2,3-e)-1,4-diazepin-2-one, 1,3,6,7,8,9-hexahydro-5-phenyl-
- CAS REGISTRY NUMBER :
- 29462-18-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C17-H16-N2-O-S
- MOLECULAR WEIGHT :
- 296.41
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 129 mg/kg/17W-I
- TOXIC EFFECTS :
- Behavioral - anorexia (human) Behavioral - muscle weakness Liver - liver function tests impaired
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 343,860,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 980 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 630 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,926,1975
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Synonyms
| Bentazepam |
| CI-718 |
| Tiadipone |
| Thiadipone |
| 1,3,6,7,8,9-Hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one |
| QM-6008 |
| 5-phenyl-1,3,6,7,8,9-hexahydro-benzo[4,5]thieno[2,3-e][1,4]diazepin-2-one |
| Bentazepamum [INN-Latin] |
| 2H-(1)BENZOTHIENO(2,3-e)-1,4-DIAZEPIN-2-ONE,1,3,6,7,8,9-HEXAHYDRO-5-PHENYL |
