CAS 2998-57-4|estramustine

Introduction：Basic information about CAS 2998-57-4|estramustine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. estramustine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	estramustine
CAS Number	2998-57-4	Molecular Weight	440.40300
Density	1.253 g/cm3	Boiling Point	565.8ºC at 760 mmHg
Molecular Formula	C₂₃H₃₁Cl₂NO₃	Melting Point	104 - 105ºC
MSDS	/	Flash Point	296ºC

Names

Name	estramustine
Synonym	More Synonyms

estramustine BiologicalActivity

Description	Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin
Target	Tubulin 1[1]
References	[1]. Dahllöf B, et al. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 1993 Oct 1;53(19):4573-81.

Chemical & Physical Properties

Density	1.253 g/cm3
Boiling Point	565.8ºC at 760 mmHg
Melting Point	104 - 105ºC
Molecular Formula	C₂₃H₃₁Cl₂NO₃
Molecular Weight	440.40300
Flash Point	296ºC
Exact Mass	439.16800
PSA	49.77000
LogP	5.18200
Vapour Pressure	1.23E-13mmHg at 25°C
Index of Refraction	1.576
InChIKey	FRPJXPJMRWBBIH-RBRWEJTLSA-N
SMILES	CC12CCC3c4ccc(OC(=O)N(CCCl)CCCl)cc4CCC3C1CCC2O

Safety Information

Hazard Codes	Xn

Synonyms

Estradiol 3-(N,N-bis(2-chloroethyl)carbamate)

[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate

Estramustina

estradiol-3-bis(2-chloroethyl)carbamate

Estramustinum

MFCD00866377

Estracyt

EINECS 221-076-3

17beta-Estradiol 3-(bis(2-chloroethyl)carbamate)

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