Introduction：Basic information about CAS 88377-68-8|Metorphamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Metorphamide |
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| CAS Number | 88377-68-8 | Molecular Weight | 984.17900 |
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| Density | 1.42g/cm3 | Boiling Point | / |
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| Molecular Formula | C44H69N15O9S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | adrenorphin |
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| Synonym | More Synonyms |
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Metorphamide BiologicalActivity
| Description | Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>CancerPeptides |
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| Target | Ki: 12 nM (μ-opioid receptor)[1] |
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| In Vitro | Adrenorphin (Metorphamide) is a opioid octapeptide from bovine brain, acts as a potent agonist of μ-opioid receptor, with Ki of 12 nM. The binding ratios of Ki for μ-opioid receptor/Ki for δ-opioid receptor of 0.04 and of Ki for μ-opioid receptor/Ki for κ-opioid receptor of 0.46[1]. Adrenorphin potently inhibits catecholamine secretion evoked by 10 μM nicotine in cultured human pheochromocytoma 6 cells, with an IC50 of 1.1 μM[2]. |
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| References | [1]. Weber E, et al. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7362-6. [2]. Yanase T, et al. Studies on adrenorphin in pheochromocytoma. J Clin Endocrinol Metab. 1987 Apr;64(4):692-7. |
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Chemical & Physical Properties
| Density | 1.42g/cm3 |
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| Molecular Formula | C44H69N15O9S |
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| Molecular Weight | 984.17900 |
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| Exact Mass | 983.51200 |
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| PSA | 442.14000 |
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| LogP | 3.10080 |
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| Index of Refraction | 1.656 |
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| InChIKey | XJOQRTJDYAHKPY-YVWIMRNGSA-N |
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| SMILES | CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(N)=O)C(C)C |
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| Storage condition | 2-8℃ |
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Safety Information
Synonyms
| H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2 |
| METORPHINAMIDE |
| METORPHAMIDE |
| PROENKEPHALIN (206-213) (BOVINE) |
| adrenorphin amide |
| TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-NH2 |
| METORPHIN |
| tyr-gly-gly-phe-met-arg-arg-val amide |
