CAS 57462-42-7|[Nle11]-Substance P
| Common Name | [Nle11]-Substance P | ||
|---|---|---|---|
| CAS Number | 57462-42-7 | Molecular Weight | 1329.592 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C64H100N18O13 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | arg-pro-lys-pro-gln-gln-phe-phe-gly-leu-nle-nh2 |
|---|---|
| Synonym | More Synonyms |
[Nle11]-Substance P BiologicalActivity
| Description | [Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Neurokinin ReceptorSignaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseasePeptides |
| In Vitro | Substance P and its analog, [Nle11]-Substance P have shown similar potency in tests. The spasmogenic activity of Substance P and [Nle11]-Substance P are preserved in the same potency order on stimulated guinea-pig ileum[1]. |
| References | [1]. Chipkin RE, et al. In vitro activities of some synthetic substance P analogs. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):193-202. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C64H100N18O13 |
| Molecular Weight | 1329.592 |
| Exact Mass | 1328.771729 |
| PSA | 516.63000 |
| LogP | -0.18 |
| Index of Refraction | 1.654 |
| InChIKey | ZEPTUBCWHRSMIP-UHFFFAOYSA-N |
| SMILES | CCCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCCN)NC(=O)C1CCCN1C(=O)C(N)CCCN=C(N)N)C(N)=O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles4
More Articles| In vitro activities of some synthetic substance P analogs. Arch. Int. Pharmacodyn. Ther. 240 , 193, (1979) Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP... | |
| Synthesis and biological activities of photoaffinity labeling analogues of substance P. J. Med. Chem. 25 , 470, (1982) Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-actin... | |
| Some observations indicating a low brain uptake of [3H]Nle11-Substance P. Pharmazie 38(2) , 108-10, (1983) The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after in... |
Synonyms
| L-Norleucinamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- |
| substance P,NleNH2(11) |
| N-(diaminomethylidene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide |
| Substance P,[Nle11] |
| [Nle11 ]-substance P |
| N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-norleucinamide |
| [Nle11]-Substance P |
