CAS 152165-14-5|H-Phe-Met-Arg-Phe-NH2 acetate salt
Introduction：Basic information about CAS 152165-14-5|H-Phe-Met-Arg-Phe-NH2 acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-Phe-Met-Arg-Phe-NH2 acetate salt | ||
|---|---|---|---|
| CAS Number | 152165-14-5 | Molecular Weight | 658.81 |
| Density | / | Boiling Point | / |
| Molecular Formula | C31H46N8O6S | Melting Point | / |
| MSDS | Chinese | Flash Point | / |
Names
| Name | fmrf amide |
|---|---|
| Synonym | More Synonyms |
H-Phe-Met-Arg-Phe-NH2 acetate salt BiologicalActivity
| Description | Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
| Target | ED50: 23 nM (K+ current)[1] |
| In Vitro | In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acetate acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide acetate activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels[1]. Phe-Met-Arg-Phe, amide (1 μM) acetate significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas[2]. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) acetate is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM)[2]. |
| In Vivo | Phe-Met-Arg-Phe, amide (FMRFamide) acetate stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 pM) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 pM) of FMRFamide is already developed after 5 min and lasted up to 30 min[3]. |
| References | [1]. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28. [2]. Sorenson RL, et al. Phe-met-arg-phe-amide (FMRF-NH2) inhibits insulin and somatostatin secretion and anti-FMRF-NH2 sera detects pancreatic polypeptide cells in the rat islet. Peptides. 1984 Jul-Aug;5(4):777-82. [3]. Ottlecz A, et al. Phe-Met-Arg-Phe-amide (FMRFamide) stimulated growth hormone secretion in conscious OVX rats. Neuropeptides. 1987 Feb-Mar;9(2):161-7. |
Chemical & Physical Properties
| Molecular Formula | C31H46N8O6S |
|---|---|
| Molecular Weight | 658.81 |
| Exact Mass | 598.30500 |
| PSA | 243.61000 |
| LogP | 3.51940 |
| InChIKey | SDZGHFARVNFBSH-JPIABUGISA-N |
| SMILES | CC(=O)O.CSCCC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O |
Synonyms
| h-phe-met-arg-phe-nh2 acoh |
| fmrf-nh2 |
| phe-met-arg-phe-nh2 |
| molluscan cardioexcitatory peptide |
| fmrfamide acetate salt |
| phe-met-arg-phe-nh2 1/2acoh 2h2o |
| h-phe-met-arg-phe-nh2 |
| phe-met-arg-phe amide |
| fmrf-amide 1 1/2acoh 2h2o |
