CAS 56-57-5|4-Nitroquinoline 1-oxide
| Common Name | 4-Nitroquinoline 1-oxide | ||
|---|---|---|---|
| CAS Number | 56-57-5 | Molecular Weight | 190.16 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 387.6±34.0 °C at 760 mmHg |
| Molecular Formula | C9H6N2O3 | Melting Point | 154-156 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 188.2±25.7 °C |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | 4-nitroquinoline N-oxide |
|---|---|
| Synonym | More Synonyms |
4-Nitroquinoline 1-oxide BiologicalActivity
| Description | Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
| References | [1]. Mukherjee A, et al. Carcinogen 4-Nitroquinoline Oxide (4-NQO) Induces Oncostatin-M (OSM) in Esophageal Cells. In Vivo. 2023 Mar-Apr;37(2):506-518. [2]. Han H, et al. 4-NQO induces apoptosis via p53-dependent mitochondrial signaling pathway. Toxicology. 2007 Feb 12;230(2-3):151-63. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 387.6±34.0 °C at 760 mmHg |
| Melting Point | 154-156 °C(lit.) |
| Molecular Formula | C9H6N2O3 |
| Molecular Weight | 190.16 |
| Flash Point | 188.2±25.7 °C |
| Exact Mass | 190.037842 |
| PSA | 71.28000 |
| LogP | 0.92 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.659 |
| InChIKey | YHQDZJICGQWFHK-UHFFFAOYSA-N |
| SMILES | O=[N+]([O-])c1cc[n+]([O-])c2ccccc12 |
| Storage condition | −20°C |
| Stability | Stable. Hygroscopic, light-sensitive. Incompatible with strong oxidizing agents. |
| Water Solubility | acetone: clear to hazy |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H350 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R33 |
| Safety Phrases | S53-S45 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | VC2100000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
Articles60
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Synonyms
| EINECS 200-281-1 |
| MFCD00006738 |
| 4-nitro-1-oxidoquinolin-1-ium |
| 4-nitroquinoline-N-oxide |
| Quinoline, 4-nitro-, 1-oxide |
| 4-Nitroquinoline 1-oxide |
| 4-nitroquinoline n-oxide |
