Introduction：Basic information about CAS 60084-10-8|Tiazofurin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tiazofurin |
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| CAS Number | 60084-10-8 | Molecular Weight | 260.267 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 641.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C9H12N2O5S | Melting Point | / |
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| MSDS | / | Flash Point | 341.6±31.5 °C |
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Names
| Name | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide |
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| Synonym | More Synonyms |
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Tiazofurin BiologicalActivity
| Description | Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH). |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. Tricot G, Jayaram HN, Weber G, Hoffman R. Tiazofurin: biological effects and clinical uses. Int J Cell Cloning. 1990;8(3):161-170. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 641.3±55.0 °C at 760 mmHg |
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| Molecular Formula | C9H12N2O5S |
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| Molecular Weight | 260.267 |
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| Flash Point | 341.6±31.5 °C |
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| Exact Mass | 260.046692 |
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| PSA | 154.14000 |
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| LogP | -1.13 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.675 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- XJ3600000
- CHEMICAL NAME :
- 4-Thiazolecarboxamide, 2-beta-D-ribofuranosyl-
- CAS REGISTRY NUMBER :
- 60084-10-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C9-H12-N2-O5-S
- MOLECULAR WEIGHT :
- 260.29
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1135 mg/kg/15D-I
- TOXIC EFFECTS :
- Behavioral - headache Musculoskeletal - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 892 mg/kg/10D-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1684 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Blood - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1090 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - fluid intake
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 3425 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 20 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,5512,1985
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2934100090 |
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Customs
| HS Code | 2934100090 |
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| Summary | 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Synonyms
| (1R)-1,4-Anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol |
| Riboxamide |
| D-Ribitol, 1-C-[4-(aminocarbonyl)-2-thiazolyl]-1,4-anhydro-, (1R)- |
| 2-b-D-Ribofuranosyl-4-thiazolecarboxamide |
| Tiazofurina [Spanish] |
| 4-Thiazolecarboxamide, 2-β-D-ribofuranosyl- |
| 2-β-D-Ribofuranosyl-4-thiazolecarboxamide |
| [3H]-Tiazofurin |
| Tiazofurine |
| Tiazole |
| Tiazofurin |
| Tiazofurina |
| Tiazofurinum |
| 2-β-D-Ribofuranosylthiazole-4-carboxamide |
| Tiazofurinum [Latin] |
