Introduction：Basic information about CAS 179343-23-8|Acetyl-CoA Carboxylase-IN-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Acetyl-CoA Carboxylase-IN-1 |
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| CAS Number | 179343-23-8 | Molecular Weight | 395.05200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C13H9Br2N5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine |
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| Synonym | More Synonyms |
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Acetyl-CoA Carboxylase-IN-1 BiologicalActivity
| Description | Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>Acetyl-CoA CarboxylaseSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; 大肠杆菌) 具有抗菌活性，对于 WT、WT+ PMBN、ΔacrAB、ΔacrAB+PMBN、ΔtolC 和 ΔtolC+ PMBN 的 MIC 值分别为 >25、3.13、25、0.39、1.56 和 0.1 μM[1]。 |
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| References | [1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525. |
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Chemical & Physical Properties
| Molecular Formula | C13H9Br2N5 |
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| Molecular Weight | 395.05200 |
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| Exact Mass | 392.92200 |
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| PSA | 90.71000 |
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| LogP | 4.54360 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 6-arylpyrido[2,3-d]pyrimidine deriv. 18 |
| QC-198 |
| 6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine |
| 2v58 |
