Introduction：Basic information about CAS 125-65-5|Pleuromutilin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pleuromutilin |
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| CAS Number | 125-65-5 | Molecular Weight | 378.502 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 482.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C22H34O5 | Melting Point | 170-171ºC |
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| MSDS | ChineseUSA | Flash Point | 158.7±22.2 °C |
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Names
| Name | Pleuromutilin |
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| Synonym | More Synonyms |
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Pleuromutilin BiologicalActivity
| Description | pleuromutilin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>InfectionNatural Products >>Terpenoids and Glycosides |
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| References | [1]. Shang RF et al. Synthesis and biological evaluation of new pleuromutilin derivatives as antibacterial agents. Molecules. 2014 Nov 19;19(11):19050-65. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 482.8±45.0 °C at 760 mmHg |
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| Melting Point | 170-171ºC |
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| Molecular Formula | C22H34O5 |
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| Molecular Weight | 378.502 |
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| Flash Point | 158.7±22.2 °C |
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| Exact Mass | 378.240631 |
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| PSA | 83.83000 |
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| LogP | 2.63 |
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| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
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| Index of Refraction | 1.538 |
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| InChIKey | ZRZNJUXESFHSIO-FEOSZSLTSA-N |
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| SMILES | C=CC1(C)CC(OC(=O)CO)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MC5408000
- CHEMICAL NAME :
- Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl- 3a,9- propano-3aH-cyclopentacycloocten-1(4H)-one
- CAS REGISTRY NUMBER :
- 125-65-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C22-H34-O5
- MOLECULAR WEIGHT :
- 378.56
- WISWESSER LINE NOTATION :
- T568/EN 2AE N BV EXTJ H1 I1 JOV1Q L1U1 L1 MQ N1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,123,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,123,1981
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| RTECS | MC5408000 |
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| HS Code | 2918199090 |
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Customs
| HS Code | 2918199090 |
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| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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| Design, synthesis, and antibacterial activity of novel pleuromutilin derivatives bearing an amino thiazolyl ring. Arch. Pharm. (Weinheim) 345(8) , 638-46, (2012) A series of novel pleuromutilin derivatives containing the amino thiazolyl ring were designed, synthesized, and evaluated for their antibacterial activities in vitro against Gram-positive clinical bac... | |
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Synonyms
| Acetic acid, 2-hydroxy-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester |
| Pleuromulin |
| Valnemulin impurity E |
| 5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate |
| Drosophilin B,Mutilin 14-glycolate |
| EINECS 204-747-5 |
| 3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl glycolate |
