CAS 526-07-8|Sesamolin

Introduction：Basic information about CAS 526-07-8|Sesamolin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Sesamolin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Sesamolin
CAS Number	526-07-8	Molecular Weight	370.353
Density	1.4±0.1 g/cm3	Boiling Point	520.8±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₈O₇	Melting Point	93 - 94ºC (Decomposes)
MSDS	/	Flash Point	219.2±30.0 °C

Names

Name	sesamolin
Synonym	More Synonyms

Sesamolin BiologicalActivity

Description	Sesaminol, isolated from Justicia orbiculata, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesaminol potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression[1][2][3][4].
Related Catalog	Signaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>MAPK/ERK Pathway >>JNK
References	[1]. Dorothea Bedigian, et al. Sesamin, sesamolin and the origin of sesame. Biochemical Systematics and Ecology. Volume 13, Issue 2, 23 May 1985, Pages 133-139. [2]. Myung-Hwa Kang, et al. Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney. The Journal of Nutrition, Volume 128, Issue 6, June 1998, Pages 1018–1022. [3]. Rolis Chien‐Wei Hou, et al. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. [4]. Lim JS, et al. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007 Jan;97(1):85-95.

Description

Sesaminol, isolated from Justicia orbiculata, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesaminol potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression[1][2][3][4].

Related Catalog

Signaling Pathways >>Apoptosis >>CaspaseSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Metabolic DiseaseResearch Areas >>Neurological DiseaseSignaling Pathways >>MAPK/ERK Pathway >>JNK

References

[1]. Dorothea Bedigian, et al. Sesamin, sesamolin and the origin of sesame. Biochemical Systematics and Ecology. Volume 13, Issue 2, 23 May 1985, Pages 133-139.

[2]. Myung-Hwa Kang, et al. Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney. The Journal of Nutrition, Volume 128, Issue 6, June 1998, Pages 1018–1022.

[3]. Rolis Chien‐Wei Hou, et al. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells.

[4]. Lim JS, et al. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007 Jan;97(1):85-95.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	520.8±50.0 °C at 760 mmHg
Melting Point	93 - 94ºC (Decomposes)
Molecular Formula	C₂₀H₁₈O₇
Molecular Weight	370.353
Flash Point	219.2±30.0 °C
Exact Mass	370.105255
PSA	64.61000
LogP	2.88
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.622
InChIKey	ZZMNWJVJUKMZJY-AFHBHXEDSA-N
SMILES	c1cc2c(cc1OC1OCC3C(c4ccc5c(c4)OCO5)OCC13)OCO2

Safety Information

Hazard Codes	Xi
WGK Germany	3.0
HS Code	29329990

Synonyms

5-[(1S,3aR,4R,6aR)-4-(1,3-Benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]fur-1-yl]-1,3-benzodioxol

5-[(1S,3aR,4R,6aR)-4-(2H-1,3-benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2H-1,3-benzodioxole

Sesamolin

5-[(1S,3aR,4R,6aR)-4-(1,3-Benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole

(1S,3aR,4R,6aR)-5-[4-(1,3-benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole

5-[4-(1,3-Benzodioxolol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole

1,3-Benzodioxole, 5-[(1S,3aR,4R,6aR)-4-(1,3-benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-

1,3-benzodioxol-5-yl (1R,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)perhydrofuro[3,4-c]furan-1-yl ether

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