CAS 53943-88-7|Letosteine

Introduction：Basic information about CAS 53943-88-7|Letosteine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Letosteine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Letosteine
CAS Number	53943-88-7	Molecular Weight	279.38
Density	1.284 g/cm3	Boiling Point	470ºC at 760 mmHg
Molecular Formula	C₁₀H₁₇NO₄S₂	Melting Point	142ºC
MSDS	/	Flash Point	238.1ºC

Names

Name	2-[2-(2-ethoxy-2-oxoethyl)sulfanylethyl]-1,3-thiazolidine-4-carboxylic acid
Synonym	More Synonyms

Letosteine BiologicalActivity

Description	Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].
Related Catalog	Research Areas >>Inflammation/Immunology
In Vivo	Letosteine (Sprague-Dawley rats, 20 mg/kg, IV or Orally, once) is rapidly excreted with mainly in urine[4]. Animal Model: Sprague-Dawley rats Dosage: 20 mg/kg Administration: IV or Orally, once Result: Rapidly was excreted with mainly in urine. More than 86% of the administered [14C]-radioactivity was recovered in urine within 72 h, 5-7% of the administered [14C]-radioactivity was recovered as 14CO2 in the expired air.
References	[1]. [1]Jia L. Letosteine. John Wiley & Sons, Ltd, 2014. [2]. [2] Macquet V, et al. A new contribution to the treatment of chronic bronchopneumopathies: letosteine. Lille Med. 1979;24(9):735-738. [3]. [3] Zhou Y, et al. Efficacy and safety of letosteine in the treatment of sputum thickening and expectoration difficulty in patients with respiratory diseases: a multicenter, randomized, double-masked, double dummy, positive drug parallel controlled trial. Pharmazie. 2014;69(11):842-849. [4]. [4] Gachon F, et al. Disposition and metabolism of letosteine in rats. Drug Metab Dispos. 1988;16(6):853-857.

Chemical & Physical Properties

Density	1.284 g/cm3
Boiling Point	470ºC at 760 mmHg
Melting Point	142ºC
Molecular Formula	C₁₀H₁₇NO₄S₂
Molecular Weight	279.38
Flash Point	238.1ºC
Exact Mass	279.06000
PSA	126.23000
LogP	1.11730
Index of Refraction	1.547
InChIKey	IKOCLISPVJZJEA-UHFFFAOYSA-N
SMILES	CCOC(=O)CSCCC1NC(C(=O)O)CS1

Safety Information

Hazard Codes	Xn
HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Viscotiol

Letosteine

Letosteinum

Letosteina

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