Introduction：Basic information about CAS 486-70-4|NSC 21723, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC 21723 |
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| CAS Number | 486-70-4 | Molecular Weight | 169.26 |
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| Density | 1.04 g/cm3 | Boiling Point | 160-164°C 4mm |
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| Molecular Formula | C10H19NO | Melting Point | 62-65°C |
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| MSDS | ChineseUSA | Flash Point | 160-164°C/4mm |
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Names
| Name | lupinine |
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| Synonym | More Synonyms |
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NSC 21723 BiologicalActivity
| Description | (-)-Lupinine is a quinolizidine alkaloid. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| References | [1]. Stephen G Davies, et al. An efficient asymmetric synthesis of (-)-lupinine. Chem Commun (Camb). 2014 Aug 7;50(61):8309-11. |
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Chemical & Physical Properties
| Density | 1.04 g/cm3 |
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| Boiling Point | 160-164°C 4mm |
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| Melting Point | 62-65°C |
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| Molecular Formula | C10H19NO |
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| Molecular Weight | 169.26 |
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| Flash Point | 160-164°C/4mm |
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| Exact Mass | 169.14700 |
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| PSA | 23.47000 |
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| LogP | 1.18110 |
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| Vapour Pressure | 0.000928mmHg at 25°C |
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| Index of Refraction | 1.525 |
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| InChIKey | HDVAWXXJVMJBAR-VHSXEESVSA-N |
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| SMILES | OCC1CCCN2CCCCC12 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OK5802000
- CHEMICAL NAME :
- Lupinine
- CAS REGISTRY NUMBER :
- 486-70-4
- BEILSTEIN REFERENCE NO. :
- 0080447
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H19-N-O
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAGRAC Journal of Agricultural Research (Washington, DC). (Washington, DC) V.1-78, 1913-49. Discontinued. Volume(issue)/page/year: 32,51,1926
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S22-S36/37 |
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| RIDADR | 1544 |
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| RTECS | OK5802000 |
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| Packaging Group | III |
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| Hazard Class | 6.1 |
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Synonyms
| LUPININE |
| EINECS 207-638-0 |
| MFCD00213431 |
| (-)-LUPININE |
| OCTAHYDRO-1H-QUINOLIZIN-1-METHANOL |
| ((1R,9aR)-Octahydro-1H-quinolizin-1-yl)methanol |
| LUPININ |
